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About Us
Patient Preparation for PET
Scans
Faculty and Staff
Our Facility
Ongoing Research
CHM PET Shareware
MicroPET
Imaging Lab
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Pulak Chakraborty, Ph. D
(313) 993-3845 (FAX)
pulak@pet.wayne.edu
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EDUCATION:
1975 B.Sc. (Hons.), Chemistry
Indian Inst. of Technology, Kharagpur, India
1977 M.Sc. (Chemistry), Special : Organic Chemistry
Indian Inst. of Technology, Kharagpur, India
1983 Ph. D., Chemistry
Calcutta University, India
TRAINING:
1985-1986 Post-doctoral Research Associate, Dept. of Chemistry
University of Illinois, Urbana-Champaign
1986-1989 Senior Research Fellow, College of Pharmacy
University of Michigan, Ann Arbor
1989-1991 Post-doctoral Fellow, Nuclear Medicine Division
University of Michigan, Ann Arbor
ACADEMIC APPOINTMENTS:
1977-1983 Research Fellow (CSIR), Dept. of Medicinal Chemistry
Indian Institute of Chemical Biology
Calcutta, India
1983-1984 Research Associate (CSIR), Dept. of Medicinal Chemistry
Indian Institute of Chemical Biology
Calcutta, India
1991-1993 Research Investigator, Nuclear Medicine Division
University of Michigan, Ann Arbor
1994 - Chemist
Pediatric Imaging Dept.
Children’s Hospital of Michigan, Detroit, MI
1994 - 2006
Assistant Professor (Clinician – Educator), Full – Time
Affiliate
Department of Radiology
Wayne State University
Detroit, MI
2006 -
Associate Professor (Clinician – Educator),
Full – Time Affiliate
Department of
Radiology
Wayne State University
Detroit, MI
MAJOR PROFESSIONAL SOCIETIES:
Member, American Chemical Society, 1987-
Member, Division of Medicinal Chemistry (ACS), 1988-
Member, Society of Nuclear Medicine, 1989-1991
Member, Society of Radiopharmaceutical Chemistry 2003-
HONORS/AWARDS:
National Scholarship (Awarded by Govt. of India), 1975-1977
Junior Research Fellowship (Awarded by Govt. of India), 1977-1979
Senior Research Fellowship (Awarded by Govt. of India), 1979-1983
National Research Service Award (USA), 1989-1991
SERVICE:
Committee Service:
Member, Radiation Safety Committee (1997), Children’s Hospital of Michigan
Patient care:
1. Synthesis of radiopharmaceuticals for clinical PET applications
2. Perform quality control, sterility and pyrogen testing procedures of all the radiopharmaceuticals
to be injected for the safety of the patients
3. Synthesis of new PET radiopharmaceuticals as they are being evaluated for future clinical
applications
Professionally related service:
1. Perform research into the development of new PET radiopharmaceuticals for clinical PET
applications
2. Prepare necessary documentation (i.e. for FDA etc) for new radiopharmaceuticals
3. Participate in the writing of grant proposals
4. Participate in teaching laboratory personnel
TEACHING:
M.S. Thesis committee member for:
Cynthia Husk Basic Medical Sciences (WSU, 2000-2001)
Supervisor for Postdoctoral Fellow:
Dilip Maiti, Ph.D. PET Radiochemistry (WSU, 2002-2004)
Wayne State University:
Radiology 7010, Winter 2001 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Production of Radionuclides"
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”
Radiology 713, Winter 2001 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry
Radiology 7010, Winter 2002 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”
Radiology 713, Winter 2002 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry
Radiology 7010, Winter 2003 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”
Radiology 713, Winter 2003 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry
Radiology 7010, Winter 2004 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”
Radiology 7010, Winter 2005 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”
Radiology 713, Winter 2005 (Course Director: Otto Muzik, Ph. D.)
4.0 h Laboratory Exercise in radiochemistry
Radiology 7010, Winter 2006 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”
Radiology 7010, Winter 2007 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”
Several lectures for students and staffs at the PET Center on radiochemistry and PET radioligands
Developments, 1994-
GRANT SUPPORT:
University of Michigan, Ann Arbor
Evaluation of cardiac autonomic innervation by PET
PI: M. Schwaiger, M. D.
Role: Co-investigator
Source: NIH (5 Years period while in Univ. of Michigan)
Non-invasive evaluation of the cardiac autonomic nervous system by PET
PI: M. Schwaiger, M. D.
Role: Co-investigator
Source: DOE (1 Year period while in Univ. of Michigan)
Wayne State University
Past:
Brain serotonin synthesis in autism
PI: Diane C. Chugani, Ph. D.
Role: Co-investigator
5% Effort
Agency: NIH
Type: R01 HD34942
Funded for period 12/15/98 to 11/30/01
Radiopharmaceutical tracers for neural progenitor cells
PI: Thomas J. Mangner, Ph. D.
Role: Co-investigator
10% Effort
Agency: DOE
Funded: 08/15/03-08/14/05
Total award $300,000 direct costs per year
Active:
Longitudinal neuroimaging in Sturge-Weber Syndrome
PI: Csaba Juhász MD, PhD
Role: Co-investigator
5% Effort
Agency: NINDS
Type: RO1-NS041922-01
Period: 7-1-03 to 6-30-07
Total award $1,100,000 direct costs
PUBLICATIONS:
1. Nasipuri D, Sarkar A, Chakraborty PK, De Dalal I: (1976)
Heterocyclic systems part III. Sulphurisation of
1-aryl-3-oxocyclohexenes as a convenient route to
hydrobenzonaphthothiophene derivatives. J. Indian Chem. Soc.
4:1232-1234.
2. Ali E, Chakraborty PK and Pakrashi SC: (1982) Condensation
of 2- hydroxytryptamine with dimethyl 4- ethyl- 4- formyl
pimelate. Heterocycles; 9:1367-1370.
3. Ali E, Chakraborty PK, Chakraborty AK, Pakrashi SC: (1982)
Synthesis and stereochemistry of ( + )- Vincatine. Heterocycles,
19:1667-1671.
4. Ali E, Roy S, Chakraborty PK, Pakrashi SC: (1983) Synthesis
and absolute stereochemistry of ( - )- Vincatine. Tetrahedron
Letters, 24:2497-2500.
5. Coates RM, Hegde S, Koch SC, Chakraborty PK: (1985) A new
synthesis of chiral methyl groups via supertritide reduction.
Elucidation of the methyl-methylene stereochemistry in kaurene
biosynthesis. Synth. Appl. Isot. Labelled Compd., Proc. Int.
Symp., 207-212.
6. Rosman LB, Chakraborty PK, Messerly EA, Sinsheimer JE:
(1988) Mutagenicity of aromatic glycidyl ethers with Salmonella.
Mutation Research, 206:115-125.
7. Sinsheimer JE, Chakraborty PK, Messerly EA, Gaddamidi V:
(1989) Mutagenicity of oxaspiro compounds with Salmonella.Mutation
Research; 224:171-175.
8. Giri AK, Messerly EA, Chakraborty PK, Hooberman BH, Sinsheimer
JE: (1990) DNA strand breaks in liver for four aliphatic epoxides
in mice. Mutation Research; 242:187-194.
9. Chakraborty PK, Kilbourn M: (1991) Oxidation of substituted
4-fluorobenzaldehydes: Application to the no-carrier-added syntheses of
4-[18F]fluoroguaiacol and 4-[18F]fluorocatechol.Applied Radiat.
Isotopes, 42: 673-681.
10. Chakraborty PK, Kilbourn MR: (1991)
[18F]Fluorination/Decarbonylation : New route to
aryl[18F]fluorides. Applied Radiat. Isotopes, 42: 1209-1213.
11. Van Dort M.E, Kilbourn M. R, Chakraborty PK, Richfield EK,
Gildersleeve DL, Wieland DM: Iodine-125 and Fluorine-18 labeled
aryl-1,4-dialkylpiperazine : (1992) Potential
radiopharmaceuticals for in vivo study of the dopamine uptake system.
Applied Radiat. Isotopes, 43: 671-680.
12. Hooberman BH, Chakraborty PK, Sinsheimer JE: (1993)
Quantitative Structure-activity relationships for the mutagenicity of
propylene oxides with Salmonella. Mutation Research, 293:85-93.
13. Rengan R, Chakraborty PK, Kilbourn MR: (1993) Can we predict
reactivity for aromatic nucleophilic substitution with [18F]fluoride
ion? J Labeled Compds. Radiopharm., 33:563-572.
14. Chakraborty PK, Gildersleeve DL, Jewett DM, Toorongian SA, Kilbourn
MR, Schwaiger M, Wieland DM: (1993) High yield synthesis of high
specific activity R-(-)[11C]epinephrine for routine PET studies in
humans. Nucl. Med. Biol., 20:939-944.
15. Del Rosario R, Jung Y -W, Carahar J, Chakraborty PK, Sherman PS,
Wieland DM: (1996) Synthesis and preliminary evaluation of
[C-11]phenylephrine as a functional heart neuronal PET agent. Nucl.
Med. Biol. 23: 611-616.
16. Chakraborty PK, Mangner TJ, Chugani DC, Muzik O, Chugani HT:
(1996) A high-yield and simplified procedure for synthesis of
a-[11C]methyl-L-tryptophan. Nucl. Med. Biol., 23:1005-1008.
17. Di Carli MF, Tobes MC, Mangner T, Levine AB, Muzik O, Chakraborty
P, Levine TB: (1997) Effects of cardiac sympathetic innervation
on coronary blood flow. New England Journal of Medicine. 336:1208-1215.
18. Nguyen NTB, DeGrado TR, Chakraborty P, Wieland DM, Schwaiger
M: (1997) Myocardial kinetics of C-11 epinephrine in the isolated
working rat heart. J Nucl Med., 38: 780-785.
19. Chakraborty PK, Mangner TJ, Chugani HT: (1997) The synthesis
of no-carrier-added [11C]urea from [11C]carbon dioxide and application
to [11C]uracil synthesis. Applied Radiat. Isotopes. 48: 619-621.
20. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Chakraborty
PK: (1997) Language and motor functions calcified
hemisphere in parents with sturge-Weber syndrome: a PET study. J. Child
Neurology. 12: 431-437.
21. Muller R-A, Rothermel RD, Muzik O, Behen ME, Chakraborty PK,
Chugani HT: (1997) Plasticity of motor organization in children
and adults. Neuroreport, 8:3103-3108.
22. Muzik O, Chugani DC, Chakraborty P, Mangner T, Chugani HT :
(1997) Analysis of [C-11]alpha-methyl-tryptophan kinetics for the
estimation of serotonin synthesis rate in vivo. J. Cereb. Blood Flow
and Metab., 17:659-669.
23. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty PK, Mangner
TJ, da Silva EA, Chugani HT: (1997) Altered serotonin synthesis
in the dentatothalamo-cortical pathway in autistic boys. Annals of
Neurology, 42: 666-669.
24. Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ,
Chakraborty PK, Chugani HT: (1997) Receptive and expressive
language activations for sentences: a PET study. Neuroreport, 8
3767-3770.
25. Muller R-A, Chugani DC, Behen ME, Rothermel RD, Muzik O,
Chakraborty PK, Chugani HT: (1997) Impairment of dentato-
thalamocortical pathway in autism: languqage activation data from PET.
Neuroscience Letters, 245: 1-4.
26. Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT:
(1998) Human brain serotonin synthesis capacity measured in vivo with
a-[11C]methyl-L-tryptophan. Synapse, 28: 33-43.
27. Muller R-A, Watson CE, Muzik O, daSilva E, Chakraborty PK, Chugani
HT: (1998) Motor organization after early middle cerebral artery
stroke : a PET study. Ped. Neurology, 19: 294-298.
28. Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ,
Chakraborty PK, Chugani HT: Brain organization of language after early
unilateral lesion. Brain and Language, 1998, 62: 422-451.
29. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AL,
Mangner TJ, Chakraborty PK: (1998) Imaging epileptogenic
tubers in children with tuberous sclerosis complex using
a-[11C]methyl-L-tryptophan PET. Ann Neurol., 44:858-866.
30. Munch G, Nguyen NTB, Nekolla S, Zieglar S, Muzik O, Chakraborty P,
Wieland DM, Schwaiger M: (2000) Evaluation of sympathetic nerve
terminals with [11C]epinephrine and [11C]hydroxyephedrine and positron
emission tomography. Circulation, 101: 516-523.
31. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R,
Mangner TJ, Chakraborty PK, Chugani HT. (2001) Autism in tuberous
sclerosis complex is related to both cortical and subcortical
dysfunction. Neurology; 57:1269-1277.
32. Pfund Z, Chugani DC, Muzik O, Juhász C, Behen ME, Lee J,
Chakraborty PK, Mangner T, Chugani HT: (2002)
a-[11C]Methyl-L-tryptophan PET in patients with alternating hemiplegia
of childhood. J Child Neurol., 17:253-260.
33. Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T,
Chakraborty PK, Sood S, Chugani HT: (2003)
Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children
with intractable epilepsy. Neurology, 60:960-968.
34. Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E,
Mangner T, Chakraborty PK, Sood S, Chugani HT: (2004) Evaluation
with __[11C]methyl-L-tryptophan PET for reoperation after failed
epilepsy surgery. Epilepsia, 45:124-30.
35. Maiti DK, Chakraborty PK, Chugani DC, Muzik O, Mangner TJ, Chugani
HT: (2005) Synthesis procedure for routine production of
[carbonyl-11C] desmethyl-WAY-100635. Applied Radiat. Isot., 62 (5):
721-727.
36. Chandana SR, Behen ME, Juhász C, Muzik O, Rothermel
RD, Thomas J. Mangner TJ, Chakraborty PK, Harry T. Chugani HT, Chugani
DC: (2005) Significance of abnormalities in developmental
trajectory and asymmetry of cortical serotonin synthesis in
autism. Int J Dev Neurosci, 23: 171-182.
37. Kagawa K, Chugani DC, Asano E, Csaba Juhász C, Otto Muzik O,
Aashit Shah A, Jagdish Shah J, Sandeep Sood S, William J. Kupsky WJ,
Thomas J. Mangner TJ, Chakraborty PK, Chugani HT: (2005) Epilepsy
surgery outcome in children with tuberous sclerosis studied with
alpha-[11C]methyl-L-tryptophan PET. Journal of Child Neurology, 20:
429-438.
38. Juhasz, Csaba; Chugani, Diane; Muzik, Otto; Wu, Dafang; Sloan,
Andrew; Barger, Geoffrey; Watson, Craig; Shah, Aashit; Sood, Sandeep;
Ergun, Eser; Mangner, Tom; Chakraborty, Pulak; Kupsky, William;
Chugani, Harry T: (2006) In vivo uptake and metabolism of
alpha-[11C]methyl-L-tryptophan in human brain tumors. Journal of
Cerebral Blood Flow & Metabolism, 26 (3): 345-347.
39. Eluvathingal, Thomas J; Behen, Michael E; Chugani, Harry T;
Jannise, James; Bernardi, Bruno; Chakraborty, Pulak; Juhasz, Csaba;
Muzik, Otto; Chugani, Diane C: (2006) Cerebellar lesions in tuberous
sclerosis complex: Neurobehavioral and neuroimaging correlates. Journal
of Child Neurology, 21 (10):846-851.
PUBLISHED ABSTRACTS
1. Ali E, Chakraborty PK, Pakrashi SC. Stereochemistry of some
isomeric tetracyclic oxindoles by NMR spectroscopy. International
Symp. on NMR in Chemistry and Biology, Calcutta, Jan. 1982.
2. Van Dort ME, Chakraborty PK, Wieland DM, Kilbourn M. Dopamine
uptake inhibitors : Comparison of 125I- and 18F-labeled
ligands. J Nucl Med.,1990; 31:898.
3. Coates RM, Pyun H-J, Chakraborty PK. Stereochemistry of proton
eliminations in terpine biosynthesis. Regional ACS Meeting, Salt
Lake City, June 1990.
4. Kilbourn MR, Chakraborty PK, Mourad A. Synthesis of F-18
labeled dopamine reuptake inhibitors. International Isotope Soc.,
3rd.Central Regional Meeting, U. S. A., Oct. 1990.
5. Chakraborty PK, Kilbourn MR. A new approach to the synthesis of no-carrier-added
fluorine-18 labeled fluorocatechols. J Labeled Compds. Radiopharm., 1991; 30: 133.
6. Chakraborty PK, Kilbourn MR. [F-18]Fluorination/Decarbonylation : New route to
aryl[F-18]fluorides. J Nucl Med.,1991; 32: 1009.
7. Chakraborty PK, Gildersleeve DL, Toorongian SA, Kilbourn MR,
Schwaiger M and Wieland DM. Syntheses of [11C]epinephrine and
other biogenic amines by direct methylation of normethyl
precursors. J Labeled Compds. Radiopharm., 1993; 32: 172.
8. Wieland DM, Chakraborty PK, Gildersleeve DL, Sherman PS, Carahar JM,
Nguyen NTB, Hutchins GD, Schwaiger M: Comparison of true and
false neurotransmitter: Evaluation of
R-(-)-[11C]epinephrine in animals. J Nucl Med., 1993; 34: 123.
9. Schwaiger M, Wierland DM, Muzik O, Chakraborty PK, Nguyen NTB,
Stafford K, Gildersleeve DL: Comparison of C-11 epinephrine and
C-11 HED for evaluation of sympathetic neurons of the heart. J
Nucl Med., 1993; 34: 13.
10. Nguyen NTB, DeGrado TR, Chakraborty PK, Stafford K, Wieland DM,
Schwaiger M: Evaluation of C-11 epinephrine in isolated working
rat heart. J Nucl Med., 1993; 34: 45.
11. VanDort M, Chakraborty PK, Wieland DM: Synthesis of
[C-11]erythro (+) meta-hydroxyephedrine (1S,2R). J Nucl Med.,
1993; 34: 236.
12. Jewett DM , Chakraborty PK: Preparation, handling and
reactivity of [11C]methyl trilate for fast Carbon-11 radiomethylation :
some new results. J Labeled Compds. Radiopharm. 1994, 35: 97.
13. VanDort ME, Chakraborty PK, Carahar J, Gildersleeve DG, Sherman PS,
Wieland DM: Search for kinetic richness: evaluation of
stereoisomers of [C-11]HED. J Nucl Med., 1994; 35: 98
14. Del Rosario RB, Jung Y-W, Chakraborty PK, Sherman PS, Wieland DM:
[C-11]Phenylephrine: marker for neuronal heart MAO. J Nucl Med., 1994; 35: 7
15. Chugani DC, Mangner TJ, Muzik O, Chakraborty PK, Behrendt DB, Chugani HT:
[C-11]Flumazenil PET in children with intractable epilepsy. Ann Neurol 36: 525-526, 1994.
16. Chugani DC, Muzik O, Mangner TJ, Chakraborty PK, Behrendt DB, Verma
NP, Chugani HT: [C-11]Flumazenil PET in patients with partial
epilepsy: Effects of sedation. Epilepsia, 1994; 35 (Suppl. 8): 21
17. Chugani DC, Chugani HT, Mangner TJ, Muzik O, Chakraborty
PK: [C-11]Flumazenil PET in children with epilepsy. J Nucl
Med., 1995; 36: 83
18. Chakraborty PK, Mangner TJ, Chugani DC, Muzik O, Chugani HT:
A high yield and simplified procedure for the synthesis of
a-[11C]methyl-L-tryptophan. J Labeled Compds. Radiopharm., 1995, 37:
619
19. Muller R-A, Chugani HT, Chakraborty PK, Mangner TJ :
Activation of calcified hemisphere in Sturge-Webber patients during
motor and language functions: A positron emission tomography study.
Epilepsia, 1995; 36 (Suppl. 4): 109
20. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Mangner TJ,
Chakraborty PK: Presurgical functional brain mapping in children's by
means of 15O-water positron emission tomography. Neurology, 1995; 45
(Suppl. 4): A295-296.
21. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Chakraborty PK:
Localization of language functions after early perisylvian lesion: A
15O-water PET study with children and adolescents. J. Cereb. Blood Flow
and Metab. 1995; 15 (Suppl. 1): S691
22. Chugani DC, Chugani HT, Mangner TJ, Muzik O, Chakraborty
PK: Localization of epileptic foci with [11C]flumazenil PET in
children. J. Cereb. Blood Flow and Metab. 1995; 15 (Suppl. 1): S179
23. Chakraborty PK, Mangner TJ, Chugani HT: The synthesis of
no-carrier-added [C-11]urea from [C-11]carbon dioxide. J. Nucl. Med.
1996; 37: 51P.
24. Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT:
Brain serotonine synthesis rate measured with
_-[C-11]methyl-L-tryptophan positron tomography in normal and autistic
subjects. Child Neurology Society Meeting, Sept. 1996.
25. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty PK, Mangner
TJ, Chugani HT: a-[C-11]Methyl-L-tryptophan PET demonstrate increased
brain serotonin rate in autistic adults. IASSID, July 1996.
26. Muzik O, Chugani DC, Chakraborty PK, Mangner TJ, Chugani HT:
Analysis of C-11 alpha-methyl-tryptophan kinetics for the estimation of
serotonin synthesis rate in human brain using dynamic PET. J. Nucl.
Med. 1996; 37: 145P.
27. Chugani DC, daSilva EA, Muzik O, Chakraborty PK, Mangner TJ,
Chugani HT: Abnonormal serotonin synthesis in epileptic foci of
children: An in vivo study with a-[C-11]methyl-tryptophan and positron
emission tomography. Epilepsia. 1997, 38: 45.
28. Chakraborty PK, Mangner TJ, Chugani HT: Synthesis of
[2-11C]thymidine from [11C]carbon dioxide. J Labeled Compds.
Radiopharm., 1997.
29. Muller R-A, Muzik O, Watson CE, daSilva E, Mangner TJ, Chakraborty
PK, Chugani HT: Motor activation in the temporal lobe following
perinatal middle cetrebral artery stroke-A single-case PET study.
Annals of Neurology, 1997; 42: 518-519.
30. Muller R-A, Muzik O, Rothermel RD, Behen ME, Downey R, Chakraborty
PK, Chugani HT: Finger movement in children: less distinct
neocortical activation profiles and reduced cerebellar involvement
compared to adults. Neuroimage, 1997, 5:S11.
31.Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty
PK, Chugani HT: Receptive and expressive language activations for
sentences. Neuroimage,1997 5:S545.
32. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AL,
Mangner TJ, Chakraborty PK: Identification of epileptogenic
tubers in children with tuberous sclerosis complex: brain seotonin
synthesis imaging with PET. Annals of Neurol., 1998, 44: 858-866.
33. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Sood S,
Mangner T, Chakraborty PK, Chugani HT: a-[11C]Methyl-L-tryptophan
(AMT) PET can detect residual epileptic cortex following failed
cortical resection in children with intractable epilepsy.
American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia
2002;43 (suppl 7):126-127.
34. Chugani HT, Juhász C, Chugani DC, Muzik O, Shah A, Asano E,
Mangner T, Chakraborty PK: Surgery for intractable infantile
spasms: the role of _[11C]Methyl-L-tryptophan (AMT) PET scanning.
American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43
(suppl 7):75-76.
35. Maiti DK, Chakraborty PK, Mangner TJ, Chugani DC, Chugani HT:
Role of tertiary amine in the condensation reaction of 11C-DWAY and
11C-WAY synthesis. 227 th. American Chemical Society National Meeting,
Medicinal Chemistry Division, 2004,p 54-55.
36. Liu J, Wu J-s, Lu X, Mangner T, Chakraborty P, Mu F, Muzik O, Peng
F: Comparative study of multiple radiopharmaceuticals for
positron emission tomography of neuroblastoma. 96 th. American
Association of Cancer Research Annual Meeting, Anaheim, CA, April
16-20, 2005.
37. Chakraborty PK, Maiti DK, Mangner TJ, Chugani DC, Chugani HT: High
yield and semi-automated synthesis procedure of (R)-[11C]PK11195. J.
Nucl. Med. 2006; 47: 522P-523P.
38. Sundaram SK, Govindan R Munian, Asano E, Juhasz C, Chakraborty PK,
Muzik O, Chugani HT, Chugani DC: Alpha-[11C]methyl-L-Tryptophan
Positron Emission Tomography (AMT- PET) predicts outcome in children
with neocortical epilepsy. American Epilepsy Society Meeting, 2006.
Epilepsia 2006;00 (suppl 0):00-00.
PRESENTATIONS:
A new approach to the synthesis of no-carrier-added fluorine-18 labeled fluorocatechol
International Symposium on Radiopharmaceutical Chemistry
Princeton, New Jersey, 1990
Platform presentation
[F-18]Fluorination/Decarbonylation: New route to aryl[F-18]fluorides
Society of Nuclear Medicine Annual Meeting, Cincinati, Ohio, 1991
Platform presentation
PET tracers for mapping both sides of the peripheral sympathetic synapse.
Nuclear Medicine Research Conference
University of Michigan Medical School, Ann Arbor, 1992
1.0 h lecture
Synthesis of Carbon-11 and Fluorine-18 labeled biogenic amines
Veteran Administration Hospital, Minneapolis, Minnesota, 1993
1.0 h lecture
Carbon-11 labelling chemistry
Nuclear Medicine Course for Basic Scientist
University of Michigan Medical School, Ann Arbor, 1993
1.0 h lecture
The synthesis of no-carrier-added [C-11]urea from [C-11]carbon dioxide.
Society of Nuclear Medicine Annual Meeting, Denver, 1996
Platform presentation
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