Positron Emission Tomography (PET) Center

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Designed by Ryan Chugani

About Us

Patient Preparation for PET Scans

Faculty and Staff

Our Facility

Ongoing Research

CHM PET Shareware

MicroPET Imaging Lab

Michael Behen, P.H. D

(313) 993-3906 (Voice)

(313) 993-3845 (FAX)

mbehen@pet.wayne.edu

   EDUCATION:
        1991               University of Michigan-Dearborn,
Honors B.A.  Psychology  (G.P.A.=3.79)

       1996                Wayne State University,
MA:  Psychology (Clinical)
Thesis:  Defensive functioning as an internal mediator of outcome in a sample of latency-aged, sexually abused children.

       2004                Wayne State University,
Doctorate: Psychology (Major=Clinical) (G.P.A.=3.83)
Dissertation:  Development and validation of the Pervasive Developmental Disorders Checklist.  

CLINICAL/RESEARCH TRAINING:
2006    Assistant Professor.  Wayne State University, Department of Pediatrics.  

2004-2006    Postdoctoral fellow. Children’s Hospital of Michigan-PET Center/Pediatrics.  Responsibilities include: research design and methodology for various projects at the PET Center; statistical analyses and interpretation, development of psychological metrics, manuscript and grant preparation/writing, and supervision of neuropsychological evaluations for all research projects;  supervision of data coding/database management; dissemination of empirical work at scientific meetings; scientific journal article review.  Also responsible for conducting [O15]water and fMRI activation studies, volumetric MRI and DTI data processing and analyses.  Region of interest (ROI) drawing, and Statistical Parametric Mapping (SPM) analyses.

1995-2004    Research Associate: Children’s Hospital of Michigan, PET Center, Department of Pediatrics, and Psychiatry and Psychology.  Responsibilities include: research design and methodology for various projects at the PET Center; statistical analyses and interpretation, development of psychological metrics, manuscript and grant preparation/writing, and administration of neuropsychological evaluations for all research projects; dissemination of empirical work at scientific meetings; scientific journal article review.  Also responsible for conducting [O15]water and fMRI activation studies, volumetric MRI and DTI data processing and analyses.  Region of interest (ROI) drawing, and Statistical Parametric Mapping (SPM) analyses.
                    
1996-1997    Clinical Placement: Detroit Receiving Hospital/University Health Center.  Trauma/outpatient therapist – Emergency, inpatient and outpatient therapy and consulting for victims (and relatives of victims) of violence/trauma.  Carry outpatient caseload for general outpatient clinic.  Psychological evaluations.  Weekly case conferences.  

1996-1998    Research assistant:  WSU Child and Family Study Group.  Responsible for project design, data collection (psychological evaluations, interview, direct observation), data analysis, presentation of scientific findings/manuscript preparation.

1993-1996                Clinical Internship:  Children’s Center of Wayne County
Outpatient therapist/psychodiagnostician.  Carry outpatient caseload of therapy clients (children, family, marital, group).  Psychological evaluations.   Weekly didactic and case conferences.

1993-2003    Psychotherapy Practicum:  Wayne State Psychology Clinic.  Therapist – carry caseload of therapy clients; individual, group psychotherapy.  Weekly supervision.

1991-1993 Assessment Practicuum:  Wayne State Psychology Clinic.  Responsible for psychological assessments.   Case supervision.

1991-1992 Clinical Placement: Lafayette Clinic
Psychometrician/research assistant.  Conduct psychological evaluations.  Data entry.

1985-1991 PH Group Home - Program Director.  Write behavioral treatment plans/programs, train staff in administering and documenting programs, monitoring client progress.

MAJOR PROFESSIONAL SOCIETIES:
American Psychological Association.
Society for Research in Child Development.
Cure Autism Now.

LICENSE:
2005    State of Michigan – Department of Community Health, Board of Psychology:  Psychologist, Limited License - Doctoral #: 63010013057         
AWARDS:
1991-1992                Thomas Rumble Fellowship, Wayne State University
1996    “With Distinction” conferred by Qualifying Examination Committee, Wayne State University, Dept. of Psychology
SERVICE:
2006-Present    Contract Psychotherapist.  Children’s Center of Wayne County; Child and Family psychotherapy.
2005-present    Contract Psychotherapist, Hegira Inc.  Livonia Counseling Center.  Outpatient psychotherapy, child, adult, family therapy.
TEACHING EXPERIENCE:                
Wayne State University
1993     Winter Term    Psych.335  Personality Psychology  (WSU Psychology Dept)
1994     Winter Term    Psych 335  Personality Psychology (WSU Psychology Dept)
            Psych 310 Abnormal Psychology (WSU Psychology Dept)
2002     Fall Term    Psych 310 Abnormal Psychology (WSU Psychology Dept)
Psych 240 Developmental Psychology (WSU Psychology Dept)
2004     Winter Term    Psych. 335 Personality Psychology (WSU College of Lifelong Learning)
2005     Fall Term    Psych 312  Brain & Behavior (WSU Psychology Department)
2006     Winter Term      Psych 240  Developmental Psychology (WSU Psychology Department)
2006     Winter Term      Psych 312 Brain & Behavior  (WSU College of Lifelong Learning)

Schoolcraft College
2005     Fall Term     Psych 153 Human Relations (Two sections) (Schoolcraft-Liberal Arts Dept)
2005     Fall Term    Psych 205 Psychology of Adjustment (Schoolcraft-Liberal Arts Dept)
2006     Winter Term      Psych 201 General Psychology

PUBLICATIONS:

A.    REFEREED JOURNAL ARTICLES

Mueller RA, Rothermel R, Behen ME, Muzik O,Chakraborty P, Chugani HT.  (1997). Plasticity of motor organization in children and adults.  Neuroreport, 8, 3103-3108.

Chugani DC, Muzik O, Rothermel R, Behen ME, Chakraborty PK, Magner TJ, Dasilva E, Chugani HT.  (1997).  Altered serotonin synthesis in the dentatothalamocortical pathway for autistic boys.  Ann Neurol, 42, 666-669.

Mueller RA, Rothermel R, Behen ME, Muzik O, Magner TJ, Chugani HT.  (1997).  Receptive and expressive language activations for sentences: A PET study.  Neuroreport, 8, 367-3770.

Mueller RA, Rothermel R, Behen ME, Muzik O, Magner TJ, Chakraborty P, Chugani HT.  (1998).  Brain organization of language after early unilateral lesion: A PET study.  Brain & Language, 62, 422-451.

Mueller RA, Rothermel R, Behen ME, Muzik O, Becker C, Fuerst D, Magner TJ, Chugani HT.  (1998).  Determination of language dominance by [O-15]water PET in children and adolescents: A comparison with the WADA test.  J Epilepsy, 11,152-161.

Mueller RA, Chugani DC, Behen ME, Rothermel R, Muzik O, Chakraborty P, Chugani HT.  (1998).  Impairment of the Dentate-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography.  Neuroscience Letters, 245, 1-4.  

Mueller RA, Behen ME, Rothermel R, Muzik O, Downey R, Magner TJ, Chugani HT. (1998).  Task-related activations in heterotopic brain malformations:  A PET study.  Neuroreport, 9, 2527-2533.

Mueller RA, Rothermel R, Behen ME, Muzik O, Magner TJ, Chugani HT.  (1998).  Different patterns of language and motor reorganization following early left hemisphere lesion.  Arch Neurol, 55, 1113-1119.

Mueller RA, Rothermel R, Behen ME, Muzik O, Magner TJ, Chugani HT.  (1998).  Develomental changes of cortical and cerebellar motor control:  A clinical PET study with children and adults.
         J Child Neurol, 13, 550-556.

Mueller RA, Rothermel R, Behen ME, Muzik O, Chakraborty P, Chugani HT. (1999).  Language organization in patients with early and late left hemispheric lesion: A PET study.  Neuropsychologia, 37, 545-57.

Mueller RA, Behen ME, Rothermel R, Muzik O, Chakraborty P, Chugani HT. (1999).  Brain organization for language in children, adolescents, and adults with left hemisphere lesion:  A PET study.  Prog Neuro-Psychopharmacol & Biol Psychiatr, 23, 657-68.

Mueller RA, Behen ME, Rothermel R, Chugani DC, Muzik O, Magner TJ & Chugani HT.  (1999). Brain mapping of language and auditory processing in high-functioning autistic adults: A PET study.  J Autism Dev. Disorders, 29, 19-31.

Chugani DC, Muzik O, Behen ME, Rothermel R, Lee J & Chugani HT.  (1999).  Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children.  Annals of Neurology, 45, 287-295.

Chugani DC, Sundram BS, Behen ME, Lee M-L & Moore GJ.  (1999).  Evidence of altered energy metabolism in autistic children.  Prog.  Neuro-Psychopharmacol.  & Biol. Psychiat.  23, 635-641.

Pfund Z, Chugani HT, Behen ME, Muzik O, Chugani DC, Nigro MA, Trock GL, Squires LA  (2000).  Lissencephaly: Fetal pattern of glucose metabolism on positron emission tomography.  Neurology, 55, 1683-1688.

Juhasz C, Behen ME, Muzik O, Chugani DC, Chugani HT. (2001). Bilateral medial frontal and bilateral temporal neocortical hypometabolism in children with epilepsy and aggression. Epilepsia, 42(8):991-1001.

Asano E, Chugani DC, Muzik O, Behen ME, Rothermel R, Magner TJ, Chakraborty PK, & Chugani HT.  (2001).  Autism in tuberous sclerosis complex:  Evidence for subcortical mechanisms.  Neurology, 9;57(7):1269-77.

Asano E, Kuivaniemi AHM, Huq M, Tromp G, Behen ME, Rothermel R, Herron J & Chugani DC. (2001).  A study on novel polymorphisms in the novel upstream region of vasoactive intestinal peptide receptor type 2 gene in autism.  Journal of Child Neurology, 16, 357-63.

Lee JS, Asano E, Muzik O, Chugani DC, Juhasz C, Pfund Z, Philip S, Behen ME, Chugani HT.  (2001).  Sturge-Weber Syndrome with unihemispheric involvment:  Correlation between clinical characteristics and FDG PET findings.  Neurology, 24;57(2):189-95.

Chugani HT, Behen ME, Muzik O, Juhasz C, Nagy F, and Chugani DC. (2001).  Local brain functional activity following early deprivation: A study of post-institutionalized Romanian orphans.  Neuroimage,14(6):1290-301.

Pfund Z, Chugani DC, Muzik O, Juhasz C, Behen ME, Lee J & Chugani HT.  (2002). a[11C]methyl-L-tryptophan PETin patients with alternating hemiplegia of childhood.  J Child Neurol, 17(4):253-60.

Lee JS, Pfund Z, Juhasz C, Behen ME, Muzik O, Chugani DC, Nigro MA, Chugani HT (2002).  Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study.  Muscle Nerve, 26(4):506-12.

Behen ME. (2004).  The Pervasive Developmental Disorders Checklist: Development and Validation.  Dissertation Abstracts International. (Dissertation)

Chandana S, Behen ME, Rothermel R, Juhasz C, Muzik O, Chugani, HT, Chugani DC. (2005).  Significance of abnormalities of developmental trajectory and asymmetry of cortical serotonin synthesis in autism.  International Journal of Developmental Neuroscience, 23, 171-82.

Eluvathingal T, Chugani HT, Behen ME, Juhász C, Muzik O, Maqbool M, Chugani DC, Makki M. Abnormal brain connectivity in children following early severe socio-emotional deprivation: a diffusion tensor imaging study. Pediatrics 2006;117:2093-100.

Eluvathingal TJ, Behen ME, Chugani DC, Janisse J, Bernardi B, Chakraborty P, Juhasz C, Muzik O, Chugani HT. Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates. J Child Neurol 2006;846-51.

Batista CEA, Chugani HT, Juhász C, Behen ME, Shankaran S. Transient hypermetabolism of the basal ganglia following perinatal hypoxia. Ped Neurol (in press)

Juhász C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol (in press)

Juhász C, Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume is a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol (in press)

Behen ME,.Chugani HT, Juhász C, Helder E, Ho A, Maqbool M, Muzik O. Abnormal Brain Tryptophan Metabolism and Clinical Correlates in Tourette Syndrome.  Movement Disorders (submitted).

Behen ME, Geenen E, Rothermel R, Muzik O, Chugani HT.  Incidence of specific absolute neurocognitive impairment in a sample of children with histories of early severe social deprivation.  Child Neuropsychology (submitted).

Sundaram SK; Sivaswamy L, Makki M, Behen ME and Chugani HT, MD.  Absence of Arcuate Fasciculus in Children with Developmental Delay of Unknown Etiology: A Diffusion Tensor Imaging Study. (Accepted pending revision in Journal of Pediatrics).

Govindan RM, Chugani HT, Makki M, Behen ME, Dornbush J, Sood S.  Plasticity of the optic radiation following unilateral occipital lobe resection: A diffusion tensor imaging study.  Epilepsia (submitted).


B. ABSTRACTS (last five years)

Juhasz C, Muzik O, Chugani DC, Rothermel R, Behen ME & Chugani HT.  Ontogeny of human GABAA     receptors studied by positron emission tomography.  Child Neurology Society, 29th Annual Meeting, San Diego, (accepted as a platform presentation).  Annals of Neurology, 2000, 48: 517.

Lee JS, Asano E, Juhasz C, Pfund Z, Behen ME, Muzik O, Chugani DC & Chugani HT.  Sturge-Weber syndrome with unihemispheric involvement:  Correlation with clinical characteristics and FDG PET findings.  Child Neurology Society, 29th Annual Meeting, Annals of Neurology.  2000; 48: 531-32.

Asano E, Chugani DC, Behen ME, Rothermel R, Muzik O & Chugani HT.  Autism in tuberous sclerosis complex: Evidence for cortical and subcortical mechanisms.  Society for.  Neuroscience. Abstracts, 2000, 26.

Asano E, Kuivaniemi AHM, Huq M, Tromp G, Behen ME, Rothermel R, Herron J & Chugani DC.  Novel polymorphisms in the novel upstream region of the VIPR2 gene in autism have a possible role in gastrointestinal problems and stereotypical behaviors in autism.  50th Annual Meeting of the American Society of Human Genetics, Philadelphia, PA, October 3-7, 2000; American Journal of Human Genetics, 67: (4) 169 Suppl. 2 Oct 2000.

Behen ME, Jacobsen L, Robbins E, Kaylor-Richardson KR, Barnett D.  Defensive functioning as an internal mediator of outcome in a sample of latency-aged, sexually abused children.  Biennial Meeting, Society for Research in Child development, 2001.

Behen ME, Chugani DC, Asano E, Lee J, Muzik O, Rothermel R, & Chugani HC.  Behavioral subtypes of autistic children show differences in regional brain serotonin synthesis. Biennial Meeting, Society for Research in Child Development, 2001.

Pfund Z, Chugani DC, Behen ME, Juhasz C, Muzik O, Lee J, & Chugani HT.   Abnormalities of GABAA receptors measured with [C-11]Flumazenil PET in autistic children.  31st Annual Meeting of the Society for Neuroscience, 2001).

Chandana S, Pfund Z, Juhasz C, Muzik O, Behen ME, Chugani HT, Chugani DC.  Re-evaluation of brain glucose metabolism abnormalities in autistic boys – An FDG PET study.  Platform Presentation, International Meeting for Autism Research, 2001.

Chandana S, Behen ME, Rothermel R, Juhasz C, Lee j, Chugani HT.  GABA receptors measured with [11c]Flumazenil PET in children with autism, Angelman, and Landau-Kleffner syndromes.  Platform Presentation, International Meeting for Autism Research, 2002.

Behen ME, Glancy L., Richardson-Kaylor K, & Robbins E.   Defensive functioning as a predictor of long-term adjustment in a sample of sexually-abused latency aged children.  Bienniel Meeting, Society for Research in Child Development, 2003.

Ho A, Chugani HT, Behen ME, Juhasz C.   PET scanning of tryptophan metabolism in Tourette’s Disorder, American Academy of Child Neurology, Annual Meeting, 2003.

Chugani HT, Juhasz C, Behen ME, Ondersma R, Muzik O, Chugani DC.  Autism with facial port-wine stain: A new syndrome.  American Academy of Child Neurology, Annual Meeting, 2003.

Chandana S, Behen ME, Rothermel R, Juhasz C, Muzik O, Chugani HT, Chugani DC.  Brain serotonerrgic abnormalities in autism.  International Meeting for Autism Research, 2004.

Chandana S, Behen ME, Rothermel R, Juhasz C, Muzik O, Chugani HT, Chugani DC. (2004).  Serotonergic abnormalities in caudate nucleus in autism.  34th Annual Meeting of the Society for Neuroscience, 2004).

Kagawa K, Chugani DC, Behen ME, Chandana S, Juhasz C, Muzik O, Chugani HT.  (2004).
    Altered brain growth in children with tuberous sclerosis complex and autism.  34th Annual Meeting of the Society for Neuroscience, 2004).

Dasan JB, Behen ME,  Makki M, Muzik O, Juhasz C, Chugani DC, Chugani HT (2004).  Abnormal brain connectivity in children with early severe social deprivation: A diffusion tensor imaging (DTI) study.  Symposium. 34th Annual Meeting of the Society for Neuroscience, 2004).

Behen ME, Chandana S, Rothermel R, Muzik O, Juhasz C, Chugani HT, Chugani DC. (2004).  Lateralized cortical serotonergic abnormalities in autistic children are associated with social subtypes.  34th Annual Meeting of the Society for Neuroscience, 2004).

Behen ME, Solomon K, Muzik O, Dasan JB, Chugani DC, Chugani HT.  (2004).  Brain activation during emotional face recognition in children with early severe social deprivation.  34th Annual Meeting of the Society for Neuroscience, 2004.

Behen ME, Chandana S, Muzik O, Juhasz C, Chugani HT, Chugani DC.  Lateralized cortical serotonergic abnormalities in autistic children are associated with social subtypes.  Symposium.  International Meeting for Autism Research, 2005.

Eluvathingal TJ, Behen ME, Makki M, Juhasz C, Muzik O, Chugani  DC, Chugani HT Abnormal language network is associated with language dysfunction in children subjected to early social deprivation: A diffusion tensor imaging study.  35th Annual Meeting for the Society for Neuroscience, 2005.

Behen ME, Eluvathingal TJ, Makki M, Juhasz C, Muzik O, Chugani  DC, Chugani HT.  Cerebellar lesions in patients with Tuberous Sclerosis Complex: neuroimaging and neurobehavioral findings.  35th Annual Meeting for the Society for Neuroscience, 2005.

Behen ME, Geenen, E, Rothermel, R, Chugani,  HT.   Incidence of specific absolute neurocognitive impairment in a sample of children with histories of early severe social deprivation.   35th Annual Meeting for the Society for Neuroscience, 2005.

Asano E, Wakamoto H, Rothermel R, Behen ME, Chugani DC, Chugani HT.  Occipital alpha Peak Frequency during Quiet Wakefulness Is an Independent Predictor of Cognitive Function in Children with Focal Epilepsy.   Joint AES/ACNS Meeting, 2005.

Geenen E, Behen, M, Rothermel R, Chugani HT.  Executive Dysfunction in children with early deprivation.  34th Annual Meeting, International Neuropsychological Society, 2006.

Rothermel R, Behen ME, Geenen E, Fish A, Chugani HT. & Chugani DC. Pilot efficacy of treatment with buspirone in autistic children: A randomized double blind study in children aged 2- 6 years of age. 5th International Meeting for Autism Research (May 2006).

Williams MT, Eluvathingal TJ, Behen ME, Chugani DC, Chugani HT.  Abnormal asymmetry in the arcuate fasciculus of autistic children: A DTI study. 5th International Meeting for Autism Research (May 2006).

Behen ME, Rothermel R,Geenen E, Stano C, Chugani DC.  Sensory problems in autism: Incidence, symptom patterns, and correlates.  5th International Meeting for Autism Research (May 2006).

Geenen E, Behen ME, Stano C, Solomon K, Rothermel R PhD & Chugani HC.  Emotion recognition deficits in children with postnatal deprivation predict internalizing problems. Poster presented at 18th Annual Meeting for Association for Psychologial Science (June 2006).
 
Behen ME, Rothermel C, Geenen E,Rothermel R & Chugani HT.  Functional brain abnormalities in language regions in language-impaired children with postnatal deprivation Poster presented at 18th Annual Meeting for Association for Psychologial Science (June 2006).

Behen ME, Juhász C, Helder E, Batista CEA, Chugani DC, Chugani HT. Cognitive function in Sturge-Weber syndrome: Efect of side and extent of severe hypometabolism on PET scanning. Ann Neurol 2006;60(suppl 3): S122. Presented at the Annual Meeting of the Child Neurology Society, Pittsburgh, PA, October 2006.

S. Sundaram, L Sivaswamy, M Makki, ME Behen, and H Chugani. Agenesis of Arcuate Fasciculus in children with global developmental delay of unknown etiology: A diffusion tensor imaging study.  Proc Int Soc Mag Reson Med, 15, (2007).
 
R. Govidan, H. Chugani, M. Makki, ME Behen, J. Dornbush, and S. Sood. Plasticity of the Optic Radiation Following Unilatooccipital Lobe Resection: A Diffusion Tensor Study.  Proc Int Soc Mag Reson Med, 15, (2007).

Sundaram, SK Sivaswamy L, Makki M, Behen ME and Chugani HT MD  Agenesis of Arcuate Fasciculus in children with global developmental delay of unknown etiology: A diffusion tensor imaging study. Accepted for poster presentation at the annual scientific meeting of ISMRM (2007).




C.    PRESENTATIONS

1993    Non-motor functions of the cerebellum.  Children’s Hospital of Michigan Neurology Grand Rounds.  Detroit, MI.
1998 Neuropsychological and FDG-PET findings in a group of children with early severe     social deprivation.  The Post-Institutionalized Child – A symposium.  Parent Network for the Post-Institutionalized Child.  Rockford Ill.
2004    Neuropsychological subgroups in Tourette’s Disorder:  Preliminary Findings.  Tourette   Syndrome Association.  Children’s Hospital of Michigan.  Detroit, MI.
2004 Neural correlates of neurocognitive and socio-emotional deficits in children experiencing early severe deprivation.  Families of Russian and Ukranian Adoption.  Improving the Lives of Children.  Ypsilanti, Michigan.
2005    Neuropsychological and AMT PET subgroups in Tourette’s Disorder.  Tourette Syndrome  Association.  Children’s Hospital of Michigan
2006    Neuropsychological and structural and functional correlates of early severe social deprivation.  Invited Talk, University of Toledo, Toledo Area Academy of Psychologists (TAAP). (To be presented March, 2006).

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