Positron Emission Tomography (PET) Center

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MicroPET Imaging Lab

Dr. Ajay Kumar, M.D., DNB, Ph. D, MNAMS

(313) 745-0668 (Voice)

(313) 993-3845 (FAX)

ajay@pet.wayne.edu

  I am working as a research Associate in the positron emission tomography (PET) center, Department of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, MI, USA since August 2006. I am involved in the analysis of PET brain scan of patients with various neurological disorders, including epilepsy, brain inflammation, brain tumor, tuberous sclerosis, etc and the evaluation of brain white matter with diffusion tensor MRI, including tractography in children with developmental delay, autism and epilepsy. I am conducting a study of memory localization in human brain with the help of 11C-leucine brain PET scan and trying to evaluate leukodystrophy, a genetic disorder of unknown etiology, and inflammatory brain disease with 11C-PK11195 brain PET scan, both of which being done for the first time. I am also actively involved in the PET study with 11C-alpha-methyltryptophan of epileptic children undergoing epilepsy surgery and diffusion tensor MRI study of various brain structures of patients with tuberous sclerosis. I regularly participate in the reporting of PET scans and attend the multi-disciplinary epilepsy surgery conferences where patient management is decided upon by consensus.
    I completed my MD (General Medicine), with honors, from Tashkent State Medical Institute-II, Tashkent, Uzbekistan. Then I did my post-graduation, MD (Biophysics) and MD (DNB) (Nuclear Medicine) and my PhD (Nuclear Medicine) from All India Institute of Medical Sciences (AIIMS), New Delhi, India.
    During my residency (MD) at AIIMS, I was posted in the department of Nuclear Medicine. Besides doing basic research work in Biophysics and working on my thesis “Role of Selenium deficiency in thyroid disorders”, I participated in all the activities of the department of Nuclear Medicine and was actively involved in numerous clinical trials such as role of 99m-Tc-DMSA in the evaluation of renal scar in diabetic patients, role of 99m-Tc-MDP bone scan/SPECT along with MRI in the evaluation of low back ache, clinical evaluation of 99m-Tc-LLEC (a glomerular agent) renal scan as a single modality to assess renal function and morphology simultaneously, role of gastroesophageal study and gastric emptying study in gastric motility disorders and post-gastric surgery, evaluation of post-traumatic bone healing with 99m-Tc-MDP bone scan/SPECT, role of 99m-Tc-DTPA GFR studies in the evaluation of patients with chronic renal failure and anaemia. I was also actively involved in red blood cell (RBC) mass estimation and RBC survival studies, done only in our department in whole India, in patients with various haematological disorders such as Thalassemia, Polycythemia, etc. I also gained experience in performing, reporting and quality assurance of various PET-CT examinations, as we had the PET-CT facility since 2005. 
    The department of Nuclear Medicine, AIIMS, conducts the largest number of nuclear neuro-imaging studies in India. These include brain imaging in patients with intractable epilepsy using ictal and interictal Tc99m ECD/HMPAO SPECT with use of MATLAB and SPM for SISCOM/SISCOS. During my residency there, I was actively involved in a multicentric study, conducted by International Atomic Energy Agency (IAEA), on comparative evaluation of Ictal brain SPECT, EEG, MRI and CT scan in the management of patients with refractory seizures in India and attended the multi-disciplinary epilepsy surgery conferences where patient management was decided upon by consensus. Besides, I also actively participated in clinical trials evaluating the role of 99m-Tc-HMPAO/ECD brain SPECT in children with attention deficit hyperactivity disorder, patients with hypertension, hyperlipidaemia, and the role of 99m-Tc-ECD, GHA & TF in differentiating remnant/recurrent tumor vs necrotic/fibrotic tissue after surgery/radiotherapy/chemotherapy in patients with brain tumor.
    I underwent training in radioiodine therapy of thyroid carcinoma and hyperthyroidism during my residency. During this period I was responsible for clinical evaluation of these patients, administration of therapeutic radio-iodine and in their post-therapy follow-up. Till 2006 more than 2800 thyroid cancer patients and 3200 hyperthyroid patients had undergone therapy and were on regular follow-up at thyroid clinic, AIIMS, the largest center in India for this purpose. I was actively associated with a randomized control trial to determine the lowest possible dose of I-131 required for remnant ablation in patients with differentiated thyroid cancer, whose results have been published in the April 2004 issue of JCEM and have led to the world wide downward change in the administered I-131 activity for this purpose. In another clinical trial, where I was actively associated, we demonstrated that I-131 ablation of intact thyroid lobe is possible in thyroid cancer patients having undergone hemithyroidectomy and lobar ablation can be an attractive alternative to surgery for those who refuse to undergo completion thyroidectomy or had complication during initial surgery. I also participated in the assessment of Tc99m-tetrofosmin and sestaMIBI as an alternative to radioiodine whole body scan in the follow-up of patients with thyroid carcinoma after radioiodine-ablation. I was also involved in a randomized control trial to evaluate the role of lithium as an adjuvant in the radioiodine treatment of hyperthyroidism and in another randomized controlled trial to assess the effect of Iopanoic Acid (Telepaque) on radioiodine Therapy of hyperthyroidism and its long-term outcome. I have independently administered P-32/Sr-89/Sm-153 therapy for skeletal metastases and intra-articular Y-90/Re-188 for radiosynevectomy in cases of arthritis.
    I did my PhD on “Dosimetric and Therapeutic Evaluation of Trans-Arterial Rhenium-188 in Cases of Inoperable Hepatocellular Carcinoma (HCC)”, a multicentric trial conducted by IAEA, which was first of its kind in that part of the world. I was personally involved in the clinical work-up, radiolabelling (of Re-188 with lipiodol), dosimetry, transarterial therapy and follow-up of liver cancer patients. I was involved in the radiological evaluation of the patients with triple phase CT scan using various reconstruction techniques such as multiplanar image reconstruction (MPR) and maximum intensity projection (MIP) and DSA guided injection of Re-188-lipiodol into the tumor after hepatic artery catheterisation. During the course of this work, I modified and simplified the dosimetric and labeling techniques, which was discussed and accepted in a IAEA research co-ordination meeting held in Dec 2003 in New Delhi, published in April 2004 issue of World Journal of Nuclear Medicine and now being followed by other participating countries. My work was accepted for platform presentation in the 51st annual meeting of Society of Nuclear Medicine (SNM), the most prestigious body of Nuclear Medicine, held in June 2004 at Philadelphia, USA and was selected for the highlight session.

Honours/ Distinctions/ Awards/ Medals/ Scholarships
1. Merit Scholarship in School and college
2. Full Scholarship for pursuing “MD” by Medical Council of India, Gvt. of India.
3. MD (General Medicine) with ‘Honours’.
4. Young Scientist/ Travel grant award for year 2000 from Asia-Oceania Federation of nuclear   medicine & biology.
5. Travel grant award in 2000 from International Thyroid Congress.
6. Travel Fellow-ship award in 2002 from Indo-American Society of Nuclear Medicine.
7. Young Scientist/ Travel grant award in year 2002 from Asia-Oceania Federation of nuclear   medicine & biology.
8. Young Scientist award in year 2003 from Asian Regional Cooperative Council for Nuclear Medicine.
9. Invited to participate and present the work in International Symposium on Nuclear Oncology, organized by International Atomic Energy Agency, in Brazil in 2004.
10. Work was selected for presentation in the “highlight session” by Prof Henry Wagner, in 47th, 49th and 53rd annual meeting of Society of Nuclear Medicine in years 2000, 2002 and 2004, respectively.
11. Was made member of National Academy of Medical Sciences, New Delhi, India in 2005.
12. First prize of “young Professional Award” in 2006 from Society of Nuclear Medicine, US.

Experiences:
  Working experience: Ten (10) years
    -One year in Safdarjung hospital, New Delhi, as resident doctor (1996-97)
    -One year in S M Hospital, New Delhi, as resident doctor (1997-98)
    -Three years in AIIMS, New Delhi, as resident doctor (1998-2001)
    -Two years in AIIMS, New Delhi, as Research Officer (2001-03)
    -Two years in AIIMS, New Delhi, as Senior Research Officer (2003-2005)
    -One year at CHM, wayne State University, Detroit, US, as Research Associate (2006- )
  Teaching experience: Eight (8) years
    -Active and compulsory participation in undergraduate and post-graduate teaching program while pursuing post-graduation and PhD.
    -Guidance and help to MSc, MD, DM, MCh students
  Reviewer (ad-hoc) for peer-reviewed international journals:
    -International Journal of Hepatology
    -Brain and Development
    -Pediatric Neurology    
    -Epilepsia
    -Developmental Medicine & Child Neurology

Membership of Professional Bodies and Organizations:
-Society of Nuclear Medicine- Northern Chapter (Receipt No. 001/01-22-2000)
-Society of Nuclear Medicine, India (A-39)
-Association of Medical Physicist of Indian (sl. No. 33/08-12-2000)
-Indian Biophysical Society (IBS/L-461)
-Indian College of Nuclear Medicine (No. 102/04-03-2000)
-National Academy of Medical Sciences, India (Ref No: 29-(3)/2004/NAMS/04-18-2005)

Paper Presentation in International and National Conferences:
-2nd Annual Conference of Nuclear Cardiology Society of India, in 1999, in New Delhi, India.
-47th annual meeting of Society of Nuclear Medicine, in 2000 at St Louis, MO, USA.
-12th International Thyroid Congress, in 2000 in Kyoto, Japan.
-33rd Annual Conference of Society of Nuclear Medicine (India), in 2001, in New Delhi, India.
-49th annual meeting of Society of Nuclear Medicine, in 2002 at Los Angeles, CA, USA.
-8th National Conference of Society of Nuclear Medicine, Bangladesh, in 2003, Dhaka, Bangladesh.
-2nd Annual General Meeting of Asia Regional Cooperative Council for Nuclear Medicine, in 2003, in         Dhaka, Bangladesh.
-6th Asia-Pacific congress of cardiovascular and Interventional Radiology, in 2004, New Delhi, India.
-International Symposium on Nuclear Oncology, in 2004, in Porto Alegre, Brazil.
-53rd annual meeting of Society of Nuclear Medicine, in 2006 at  San Diego, CA, USA.

Workshop and CME attended:

-13th International Biophysics Congress, in 1999, in New Delhi, India.
-Regional training workshop on Myocardial Perfusion Scintigraphy using SPECT for Nuclear Medicine Physicians, organized by International Atomic Energy agency in 2000, in New Delhi, India.
-Workshop on Alzheimer’s disease, conducted by All India Institute of Medical Science, in 2001, in New Delhi, India.
-National Symposium on “Statistical & Mathematical Techniques and Radiation Safety in Nuclear Medicine” in 2001, in New Delhi, India.
-Regional training workshop on Radionuclide Treatment of Liver Cancer, organized by International Atomic Energy agency (IAEA), in 2002, in Ho Chi Minh City, Vietnam.
-CME of Society of Nuclear Medicine, in 2002, at Los Angeles, CA, USA.
-CME on Current Perspective in Liver Desease, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.
-Nephrology Update, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.
-CME on “Radiological Protection of Patients in Use of Ionizing Radiation” and “Management of Radiation Accidents & Emergencies” in 2002 in Lucknow, India.
-International Symposium on Nuclear Oncology, organized by International Atomic Energy agency (IAEA), in 2004, in Porto Alegre, Brazil.
-National Workshop on PET-CT by Indian College of Nuclear Medicine in 2005 in New Delhi, India.
-International Scientific Exchange Program of American Association of Physicists in Medicine in 2006, in New Delhi, India.
-International Symposium on Advances in Diagnostic Medical Physics and Workshop on “Cyclotron-PET-CT” in 2006 in New Delhi, India.

 List of Publications (full papers and abstracts)
1. Bal C S, Kumar A, Dwivedi SN. Radioiodine ablation of contralateral normal lobe in low-risk carcinoma thyroid patients following hemithyroidectomy. J Nucl Med 1999; 40: 207
2. Bal C S, Kumar A, Goswami RK. A prospective randomized control trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyrpoidism. J Nucl Med 1999; 40: 209
3. Bal C S, Kumar A, Pant GS. Radioiodine ablation of remaining thyroid lobe/tissue following hemithyroidectomy or subtotal thyroidectomy in low-risk patients with differentiated carcinoma thyroid. Ind J Nucl Med 1999; 14: 112.
4. Bal C S, A Kumar, Mukhopadhyaya S. detection of X-Ray negative pulmonary metastasis by high resolution CT scan in differentiated thyroid carcinoma and their outcome after radioiodine therapy. Endocrinol Jap 2000; 47: 135.
5. Gopal V Punjabi, A Kumar, R Goswami, C S Bal. Prevalence of UTI and detection of renal scars by 99mTc DMSA scanning in diabetes Mellitus- A case control study. J Nucl Med 2000;
6. Bal C S, Kumar A, S Barai, G V Punjabi, A Naik, G P Bandopadhyaya, S Aggarwal, A Malhotra, V S Mehta. Role of 99mTc-GHA brain SPECT in differentiating recurrent glioma from radiation necrosis. EJNM 2000; 27: 997.
7. Ajay kumar, Pandey R M, Bal C S. A prospective randomized control trial to evaluate the adjuvant effect of Lithium on radioiodine treatment of hyperthyroidism. Endocrinol Jap 2000; 47: 247.
8. Bal CS, Kumar A, Senthil kumar, G V Punjabi, J B Dasan, Bhatia M, Padma MV, Gaikwad S, Singh VP, Jain S, Gupta S, Sarkar C. Role of Ictal and Interictal Tc99m-HMPAO/ECD SPECT in the evaluation of Surgically remediable epilepsy: Outcome in first 55 operated patients. EJNM 2000; 27: 938.
9. G V Punjabi, M Mighlani, A Kumar, J B Dasan, P K Dave, C S Bal. Comparison of bone scan and SPECT with structural imaging in diagnosing cause of low backache. EJNM 2000; 27: 920.
10. Ajay Kumar, Bal C S, Padhy A K. Clinical feature of differentiated thyroid carcinoma in children and adolescents in endemic iodine deficient area. Turk J Nucl Med 2000; 9 (3): 67.
11. Bal CS and Ajay Kumar. Radionuclide imaging in Urinary infections. Pediatric Today 2000; 6: 408-410.
12. CS Bal and Ajay kumar. Follicular carcinoma presenting with an isolated scapular metastasis. IJNM 2000; 15(1): 30-32.
13. Bal CS, Padhy AK and Kumar A. Clinical features of differentiated thyroid carcinoma in children and adolescents from a sub-Himalayan iodine-deficient endemic zone. Nucl Med Comm, 2001; 22: 881-7.
14. Amite Pankaj, Ajay Kumar, CS Bal et al. Role of three phase bone scintigraphy in the early diagnosis of reflex sympathetic dystrophy of the hand. EJNM 2001; 28: 1167.
15. Ajay kumar, CS Bal, Abhijit Ghosh et al. Role of GFR and ERPF in predicting renal dysfunction in anaemic patients with normal serum biochemistry. EJNM 2001; 28: 1221-1222.
16. Gopal V Punjabi, Ajay Kumar, CS Bal. Prognostic value of flow cytometric DNA measurements in Indian Patients with thyroid cancer. EJNM 2001; 28: 1174.
17. CS Bal, A Kumar and GS Pant. How small should “small dose” of radioiodine be for remnant ablation in differentiated thyroid carcinoma: A prospective randomized clinical trial in 372 patients. JNM 2001; 42: 158.
18. Chandrashekar N, Ajay Kumar, M tripathi, Hentok Phom, Thomas EJ and CS Bal. Evaluation of L,L-Ethyl cysteine in healthy Indian adults. IJNM 2001; 16: 144.
19. N Chandrashekar, S Guleria, M Tripathi, Ajay Kumar and CS Bal. Role of Tc-99m L, L-ethyl cysteine in evaluation of renal transplant patients: initial experience. IJNM 2001; 16: 146.
20. CS Bal, K Gupta, A Kumar, Chandrashekar N, V P Choudhury, R Kashyap, M Mahapatra and A K Padhy. Role of Cr-51-RBC survival studies in the management of hypersplenism. IJNM 2001; 16: 174.
21. Madhavi T, Chandrashekar N, Thomas EJ, Hentok P, Naveen K, Ajay Kumar, R Kumar, A Malhotra and CS Bal. Hepatobiliary scintigraphy is very crucial in the management of bile leak following laparoscopic cholecystectomy. Nucl Med Comm 2002; 23: 399.
22. Chandrashekar N, Ajay Kumar, Thomas EJ, Madhavi T, Hentok P, Naveen K, A Malhotra and C S Bal. 99mTc-l,l-ethyl cysteine renal scan as a single modality investigation for the evaluation of renal morphology and function: a comparative study with 99mTc-DMSA renal scan. Nucl Med Comm 2002; 23: 399.
23. A Kumar, N Keshary, H Phom, N Chandrashekar, E J Thomas, M Tripathi, P S N Menon, K Anand, R M Pandey, C S Bal. A large proportion of children with Down syndrome suffer from thyroid dysfunction. JNM 2002; 43: 330.
24. A Kumar, H Phom, E J Thomas, N Chandrashekar, M Tripathi, A Malhotra, R Kashyap, V P Choudhry, C S Bal. Detection of accessory spleen following splenectomy in cases of chronic Idiopathic Thrombocytopenic Purpura. JNM 2002; 43: 79-80.
25. E J Thomas, N Chandrashekar, A Kumar, H Phom, M Tripathi, P K Julka, V P Singh, C S Bal. 99mTc Glucoheptonate Brain SPECT: an Invaluable Tool in the Management of Post-Operative Patients with Primary Brain Tumors Receiving Radiotherapy; Correlative Study with CT, MRI and Clinical Outcome in 140 Patients. JNM 2002; 43: 249.
26. C S Bal, A Kumar. Can Iopanoic Acid (Telepaque) be used for rapid control of hyperthyroidism prior to 131I therapy: long-term outcome of a randomized control trial. JNM 2002; 43: 125-126.
27. Tripathi M, Chandrashekar N, Thomas EJ, Naveen K, Ajay Kumar, CS Bal, A Malhotra. Efficacy of F+0 diuresis renography with 99mTc-EC in the evaluation of dilated upper tract in infants & children. EANM-2002; A 2555.
28. A. Kumar, H.Phom, P. Akshay, N. Chandrashekar, M. Tripathi, E.J.Thomas, M.Srinivas, V. Bhatnagar, C.S. Bal.  Evaluation of cerebral vascular reserve by 99m-Tc-ECD brain Spect: is it a sensitive prognostic parameter in the management of congenital hydrocephalus?  WFNMB 2002; 2568.
29. A. Kumar, H.Phom, E.J. Thomas, M. Tripathi, N. Chandrashekar, H Zamir, S. Gulati, V.Kalra, C.S. Bal.  Role of 99mTc-ECD brain SPECT in the detection of cerebral perfusion abnormality in cases of attention Deficit Hyperactivity Disorder.  WFNMB 2002; 2573.
30. A. Kumar, P.Hentok, N. Chandrashekar, E.J. Thomas, M. Tripathi, A. Ghosh, B.L. Jaikhani, O.P. Malhotra, C.S. Bal.  Effect of severe anaemia on renal function: a case-control study.  WFNMB 2002; 2566.
31. Bal CS, Kumar A and Pandey RM. A randomized controlled trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyroidism. Thyroid 2002; 12: 399-406.
32. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Differentiated thyroid carcinoma in children and adolescents: clinical features and outcome of radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 4.
33. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Clinical Characteristics of X-ray negative pulmonary metastasis from differentiated thyroid carcinoma in children and adolescents and their outcome after radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 25.
34. Thomas EJ, J. Bharathi Dasan, N. Chandrasekhar, M. Tripathi, R. Kumar, A. Kumar, D.K. Gupta, D.K. Mitra, A. Malhotra. Detection of gastroesophageal reflux in survivors of congenital diaphragmatic hernia: A radionuclide scintigraphic study in 26 children. WFNMB 2002: 1; A 320.
35. Thomas EJ, J. Bharathi Dasan, R. Kumar, N. Chandershekher, M. Tripathi, A. Kumar, S. Menon, S.K. Kabra, A. Malhotra. Silent gastro-esphageal reflux in children presenting with recurrent lower respiratory tract infections. WFNMB 2002: 1; A 321.
36. Thomas EJ, M. Hadi, M. Tripathi, A. Kumar, J. Bharathi Dasan, N. Chandershekhar, S. Agarwala, C.S. Bal, R. Kumar. Direct radionuclide cystography by suprapublic puncture method – a comparison with micturating cystouretherography in 45 children on follow up for vesico ureteric reflux. WFNMB 2002: 1; A 322.
37. Bal CS, Kumar A, Padhy AK, Bahadur S. Role of bone scan in the management of squamous cell carcinoma of oral cavity. World J Nucl Med 2002; 1:29-34.
38. Y G Rao, Ajay Kumar, G K Pande, P Sahni, T K Chattopadhyay, K Gupta, S Aggarwal, G P Bandopadhyay and C S Bal. Role of 99mTc-DTPA GFR estimation in the evaluation of the effect of preoperative hydration and low dose dopamine infusion on renal function in patients undergoing surgery for obstructive jaundice. BJNM 2003. 6; 62-63.
39. Ajay Kumar, Srinivasan J V, Phom H, Chandrashekhar N, Tripathi M, C S Bal. Role of bone scan in assessing the fracture healing and predicting the outcome of fracture shaft femur, managed by rimmed intramedullary interlocking. JNM 2003; 44: A 652687. 
40. Ajay Kumar, G S Pant, C S Bal. Clinical characteristics of pulmonary metastasis from differentiated thyroid carcinoma in children and adolescents and their outcome after radioiodine therapy. JNM 2003; 44: A 652678.
41. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K Acharya, K R sundaram and G S Pant. Role of dosimetry in transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma. World congress on Medical Physics and Biomedical Engineering 2003: A 2065.
42. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K Acharya, K R sundaram and G S Pant. Is scatter correction necessary for the dosimetry in transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma? World congress on Medical Physics and Biomedical Engineering 2003: A 2069.
43. A Kumar, P Chandra, N K Gowda, N Murali, S Choudhury, N Chandrasheker, S Sen, J Bharathidasan, S Aggarwal, G P Bandopadhyaya and C S Bal. Critical evaluation of the role of 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin (TF) in post-surgical follow-up of the patients with differentiated thyroid cancer: a clinical trial. JSNM 2003.
44. Kumar A, Bal CS. Differentiated Thyroid Cancer. Ind J Pediatr 2003; 70:707-713.
45. C S Bal, Ajay Kumar, M Tripathi, and G S Pant. High dose radioiodine treatment is not associated with change in fertility or any genetic risk to the offspring. Ind J Nucl Med 2003; 18 (4): 22-23.
46. M Tripathi, N Chandrasekhar, N K Gowda, A Kumar, C S Bal. Effectiveness of Sm-153 therapy in pain palliation from skeletal metastases of carcinoma breast and carcinoma prostate. Ind J Nucl Med  2003; 18 (4): 22.
47. Bal CS, Kumar A, Pant GS. Radioiodine lobar ablation as an alternative to completion thyroidectomy in patients with differentiated thyroid cancer. Nucl Med Comm 2003; 24: 120-6.
48. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, G K Pandey, S DattaGupta, K R sundaram, Pat Zanzonico, Felix X Sundaram, A K Padhy and C S Bal. Transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma. WJNM 2004; 3: S130-131.
49. Bal CS, Kumar A, Chandra P, Dwivedi SN, Mukhopadhyaya S. Is Chest X-ray or High-Resolution Computed Tomography Scan of the Chest Sufficient Investigation to Detect Pulmonary Metastasis in Pediatric Differentiated Thyroid Cancer? Thyroid 2004; 14: 221-229.
50. Narayana C, Tripathi M, Kumar A, Gowda NK, Phom H, Chandra P, Bandopadhyaya G, Bal C. Technetium-99m-L,L-ethylenedicysteine renal scan as a single-modality investigation for the evaluation of renal morphology and function: a comparative study with technetium-99m-dimercaptosuccinic acid. Nucl Med Commun. 2004 Jul; 25(7):743-747.
51. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C S Bal. Trans-hepatic-arterial Re-188 labeled lipiodol therapy (TART) in cases of inoperable hepatocellular carcinoma (IHCC)- a prospective clinical trial. JNM 2004; 45 (5):147P-148P.
52. A Kumar, M R Nadig, P Chandra, M Sahoo, G S Pant and C S Bal. Can radioiodine ablation be an effective alternative to completion thyroidectomy in patients undergoing subtotal thyroidectomy (STT) and if yes, what is the optimum 131I administered activity required: a prospective clinical trial. JNM 2004; 45 (5):19P.
53. N Chandrashekar, M Tripathi, A Kumar, N K Gowda, M R Nadig, C Patel, A Malhotra, S Guleria and C S Bal. Evaluation of 99mTc-L,L-Ethyl Cysteine in renal transplant patients: A comparative study with 99mTc-MAG3 and 131I-OIH. JNM 2004; 45 (5):314P.
54. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C S Bal. Dosimetric and therapeutic evaluation of trans-arterial Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC)-a prospective multicentric clinical trial. 8th AOFNMB 2004; A213.
55. Bal CS, Kumar A, Pant GS. Radioiodine dose for remnant ablation in differentiated thyroid carcinoma: a randomized clinical trial in 509 patients. J Clin Endocrinol Metab. 2004 Apr; 89(4):1666-73.
56. Phom H, Kumar A, Tripathi M, Chandrashekar N, Choudhry VP, Malhotra A, Bal CS. Comparative evaluation of Tc-99m-heat-denatured RBC and Tc-99m-anti-D IgG opsonized RBC spleen planar and SPECT scintigraphy in the detection of accessory spleen in postsplenectomy patients with chronic idiopathic thrombocytopenic purpura. Clin Nucl Med. 2004 Jul; 29(7): 403-9.
57. D N Srivastava, Ajay Kumar, S K Acharya, Sanjay Thulkar, Sanjay Sharma, G K Pandey, S Duttagupta, K R Sundaram, G P Bandopadhyaya, G S Pant, A Malhotra and C S Bal. Trans-arterial radionuclide therapy (TART) in cases of inoperable hepatocellular carcinoma (HCC)- a prospective clinical trial. 6th APCCIR 2004: 324-325.
58. G Bhaskar, A Kumar, P Chandra, S Gulati, A K Gupta, V Kalra, C S Bal.  Prevalence of gastroesophageal reflux in children with developmental delay: A prospective clinical trial.  J. Nucl Med 2005; 46: 224P.
59. S Kattimani, A Kumar, R Sagar, C S Bal.  Role of 99mTc-ECD Brain SPECT in the evaluation of patients with catatonia: A prospective clinical Trial.  J Nucl Med 2005; 46: 215P.
60. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, and Bal CS. Adrenal and Renal Metastases from Follicular Thyroid Cancer. BJR 2005; 78: 1038-1041.
61. Bal C, Kumar A, Tripathi M, Chandrashekar N, Phom H, Murali NR, Chandra P, Pant GS.  High-dose radioiodine treatment for differentiated thyroid carcinoma is not associated with change in female fertility or any genetic risk to the offspring. Int J Radiat Oncol Biol Phys 2005; 63: 449-455.
62. CS Bal, T Singhal, K Naveen, M Tripathi, GS Pant, CD Patel, R Kumar, A Kumar, SK Saw, A Malhotra. 18F-FDG PET-CT in 131I WBS negative thyroid cancer: an initial experience. IJNM 2005; 20 (4): 119.
63. Kumar A, Bal CS, Srivastava DN, Acharya SK, Thulkar S, Sharma S, Duttagupta S. Transarterial Radionuclide Therapy with Re-188-HDD-lipiodol in Case of Unresectable Hepatocellular Carcinoma with Extensive Portal Vein Thrombosis. EJR (extra) 2005; 2005; 56 (2): 55-59.
64. Bal CS and Kumar A. Alternative Strategies in the Management of De-Differentiated Thyroid Cancer. Ind J Oncol 2005; 26: 28-41.
65. Bal CS, Kumar A, Chandra P. Effect of Iopanoic Acid (Telepaque) on Radioiodine Therapy of Hyperthyroidism: Long-Term Outcome of a Randomized Controlled Trial. JCEM 2005; 90: 6536-6540.
66. CS Bal, T Singhal, R Kumar, R Verma, P Chandra, A Kumar, GS Pant. Long term outcome of radioiodine lobar ablation in patients with differentiated thyroid cancer. JNM 2006; 47 (Suppl 1): 324.
67. A Kumar, C Bal, DN Srivastava, P Chandra, SK Acharya, GS Pant, GP Bandopadhyaya. Dosimetric and therapeutic evaluation of trans-arterial Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC). JNM 2006; 47 (Suppl 1): 105.
68. A Kumar, C Bal and DN Srivastava. Modified labeling technique of Rhenium (Re)-188-HDD lipiodol for transarterial radionuclide therapy in liver cancer. JNM 2006; 47 (Suppl 1): 528.
69. Prem Chandra, CS Bal, SN Dwivedi, Ajay Kumar, Arvind Pandey. An applicability of imputation analysis in clinical trial on remnant ablation in differentiated thyroid cancer. Clinical Trials 2006; 3(1): 208
70. Kumar A, Bal C, Srivastava DN, Thulkar SP, Sharma S, Acharya SK, Duttagupta S.  Management of multiple intrahepatic recurrences after radiofrequency ablation of hepatocellular carcinoma with rhenium-188-HDD-lipiodol. Eur J Gastroenterol Hepatol 2006;18(2): 219-23.
71. Kumar A, Srivastava DN, Bal CS. Management of Post-Surgical Recurrence of Hepatocellular Carcinoma with Transarterial Radionuclide Therapy. J Vasc Interv Radiol 2006; 17(1): 157-61.
72. CS Bal, Ajay Kumar, Prem Chandra, S N Dwivedi, G S Pant. A prospective clinical trial to assess the efficacy of radioiodine ablation as an alternative to completion thyroidectomy in patients with differentiated thyroid cancer undergoing sub-total thyroidectomy. Acta Oncol. 2006;45(8):1067-72.
73. Ajay Kumar, DN Srivastava, Trinh Thi Minh Chau, Huynh Duc Long, CS Bal, Prem Chandra, Le Truong Chien, Nguyen Van Hoa, S Thulkar, S Sharma, Le Huu Tam, Truong Quang Xuan, Nguyen Xuan Canh, GS Pant, GP Bandopadhyaya. Transarterial Re-188-HDD-Lipiodol in the treatment of Inoperable Hepatocellular Carcinoma: a Prospective Multicenter Clinical Trial. Radiology 2007; 243:509-519.
74. Prem Chandra S.N. Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey. Utility of imputation analysis in clinical trial on remnant ablation of differentiated thyroid cancer patients. Accepted for publication in “Statistics in Transition”.
75. Bernal Patricia, Raoul Jean-Luc, Vidmar Gay, Sereegotov C, Sundram Felix X, Kumar A, J-M Jeong, Pusuwan P, Divgi Chaitanya, Zanzonico Pat, Stare Janez, Chau T, Saw M, Chen SL, Ogbac R, Buscombe JR, Padhy Ajit K. Intra-arterial Rhenium-188 Lipiodol in the treatment of inoperable hepatocellular carcinoma: results of an IAEA-sponsored multi-nation study. Accepted for publication in “International Journal of Radiation Oncology, Biology, Physics”.

List of Publications (Book chapters)
1. CS Bal and Ajay Kumar. “Radionuclide imaging” In “Pediatric Nephrology” RN Srivastav and A Bagga (eds), 3rd Edition, Jaypee Brothers , New Delhi, 2001, pp39-49.
2. CS Bal & A Kumar. “Radioisotopes and their applications in Medicine”. In “Text Book of Biochemistry and Human Biology”. GP Talwar and LM Srivastav (eds), Pritice Hall India, New Delhi,2002,pp1189-1214.
3. CS Bal and Ajay Kumar. Radionuclide imaging. In R N Srivastava and A Bagga eds. Pediatric Nephrology. New Delhi: Jaypee Brothers, 2004: 45-57.
4. CS Bal and Ajay Kumar. Nuclear Imaging in vesico-ureteric reflux. In M Bajpai, J P Gearhart, K Hjalmas eds. Progress in pediatric Urology. New Delhi: Penwel publishers plc, 2005: 50-59.
5. CS Bal and Ajay Kumar. “Role of Radionuclide Investigations in Surgical Practices”. In “Essentials of Surgery”. Sunil Chumbar(ed), Jaypee Brothers, New Delhi, 2005; 336-344.
6. Prem Chandra, SN Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey, KR Sundaram, Padam Singh. On the use of consort statement in clinical trial on remnant ablation of differentiated thyroid cancer. In Arvind Pandey ed. Biostatistical aspects of health and population. New Delhi: Hindustan publishing corporation (India), 2006: 41-45.
7. Bal CS and Ajay Kumar. Nuclear Imaging in Paediatric Surgery. In D K Gupta ed. Pediatric Surgery. (in press)
8. CS Bal and Ajay Kumar. Differentiated Thyroid Cancer in Childhood and Adolescence. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, (in press).
9. CS Bal and Ajay Kumar. Prognostic factors and risk group analyses in patients with differentiated thyroid carcinoma. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, (in press).
10. CS Bal and Ajay Kumar. Role of Chemotherapy in the management of Thyroid Carcinoma. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, (in press).
11. CS Bal and Ajay Kumar. Thyroglobulin. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, (in press).
12. Sundaram SK, Ajay Kumar and GP Bandopadhyaya. Radiopharmaceuticals in clinical nuclear medicine. In GS Pant ed. (in press)
13. Sundaram SK and Ajay Kumar. PET Quantification. In GS Pant ed. (in press)

 

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