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Dr. Ajay Kumar, M.D., DNB, Ph. D, MNAMS
(313) 993-3845 (FAX)
ajay@pet.wayne.edu
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I
am working as a research Associate in the positron emission tomography
(PET) center, Department of Pediatrics and Neurology, School of
Medicine, Wayne State University, Detroit, MI, USA since August 2006. I
am involved in the analysis of PET brain scan of patients with various
neurological disorders, including epilepsy, brain inflammation, brain
tumor, tuberous sclerosis, etc and the evaluation of brain white matter
with diffusion tensor MRI, including tractography in children with
developmental delay, autism and epilepsy. I am conducting a study of
memory localization in human brain with the help of 11C-leucine brain
PET scan and trying to evaluate leukodystrophy, a genetic disorder of
unknown etiology, and inflammatory brain disease with 11C-PK11195 brain
PET scan, both of which being done for the first time. I am also
actively involved in the PET study with 11C-alpha-methyltryptophan of
epileptic children undergoing epilepsy surgery and diffusion tensor MRI
study of various brain structures of patients with tuberous sclerosis.
I regularly participate in the reporting of PET scans and attend the
multi-disciplinary epilepsy surgery conferences where patient
management is decided upon by consensus.
I completed my MD (General Medicine), with honors,
from Tashkent State Medical Institute-II, Tashkent, Uzbekistan. Then I
did my post-graduation, MD (Biophysics) and MD (DNB) (Nuclear Medicine)
and my PhD (Nuclear Medicine) from All India Institute of Medical
Sciences (AIIMS), New Delhi, India.
During my residency (MD) at AIIMS, I was posted in
the department of Nuclear Medicine. Besides doing basic research work
in Biophysics and working on my thesis “Role of Selenium
deficiency in thyroid disorders”, I participated in all the
activities of the department of Nuclear Medicine and was actively
involved in numerous clinical trials such as role of 99m-Tc-DMSA in the
evaluation of renal scar in diabetic patients, role of 99m-Tc-MDP bone
scan/SPECT along with MRI in the evaluation of low back ache, clinical
evaluation of 99m-Tc-LLEC (a glomerular agent) renal scan as a single
modality to assess renal function and morphology simultaneously, role
of gastroesophageal study and gastric emptying study in gastric
motility disorders and post-gastric surgery, evaluation of
post-traumatic bone healing with 99m-Tc-MDP bone scan/SPECT, role of
99m-Tc-DTPA GFR studies in the evaluation of patients with chronic
renal failure and anaemia. I was also actively involved in red blood
cell (RBC) mass estimation and RBC survival studies, done only in our
department in whole India, in patients with various haematological
disorders such as Thalassemia, Polycythemia, etc. I also gained
experience in performing, reporting and quality assurance of various
PET-CT examinations, as we had the PET-CT facility since 2005.
The department of Nuclear Medicine, AIIMS, conducts
the largest number of nuclear neuro-imaging studies in India. These
include brain imaging in patients with intractable epilepsy using ictal
and interictal Tc99m ECD/HMPAO SPECT with use of MATLAB and SPM for
SISCOM/SISCOS. During my residency there, I was actively involved in a
multicentric study, conducted by International Atomic Energy Agency
(IAEA), on comparative evaluation of Ictal brain SPECT, EEG, MRI and CT
scan in the management of patients with refractory seizures in India
and attended the multi-disciplinary epilepsy surgery conferences where
patient management was decided upon by consensus. Besides, I also
actively participated in clinical trials evaluating the role of
99m-Tc-HMPAO/ECD brain SPECT in children with attention deficit
hyperactivity disorder, patients with hypertension, hyperlipidaemia,
and the role of 99m-Tc-ECD, GHA & TF in differentiating
remnant/recurrent tumor vs necrotic/fibrotic tissue after
surgery/radiotherapy/chemotherapy in patients with brain tumor.
I underwent training in radioiodine therapy of
thyroid carcinoma and hyperthyroidism during my residency. During this
period I was responsible for clinical evaluation of these patients,
administration of therapeutic radio-iodine and in their post-therapy
follow-up. Till 2006 more than 2800 thyroid cancer patients and 3200
hyperthyroid patients had undergone therapy and were on regular
follow-up at thyroid clinic, AIIMS, the largest center in India for
this purpose. I was actively associated with a randomized control trial
to determine the lowest possible dose of I-131 required for remnant
ablation in patients with differentiated thyroid cancer, whose results
have been published in the April 2004 issue of JCEM and have led to the
world wide downward change in the administered I-131 activity for this
purpose. In another clinical trial, where I was actively associated, we
demonstrated that I-131 ablation of intact thyroid lobe is possible in
thyroid cancer patients having undergone hemithyroidectomy and lobar
ablation can be an attractive alternative to surgery for those who
refuse to undergo completion thyroidectomy or had complication during
initial surgery. I also participated in the assessment of
Tc99m-tetrofosmin and sestaMIBI as an alternative to radioiodine whole
body scan in the follow-up of patients with thyroid carcinoma after
radioiodine-ablation. I was also involved in a randomized control trial
to evaluate the role of lithium as an adjuvant in the radioiodine
treatment of hyperthyroidism and in another randomized controlled trial
to assess the effect of Iopanoic Acid (Telepaque) on radioiodine
Therapy of hyperthyroidism and its long-term outcome. I have
independently administered P-32/Sr-89/Sm-153 therapy for skeletal
metastases and intra-articular Y-90/Re-188 for radiosynevectomy in
cases of arthritis.
I did my PhD on “Dosimetric and Therapeutic
Evaluation of Trans-Arterial Rhenium-188 in Cases of Inoperable
Hepatocellular Carcinoma (HCC)”, a multicentric trial conducted
by IAEA, which was first of its kind in that part of the world. I was
personally involved in the clinical work-up, radiolabelling (of Re-188
with lipiodol), dosimetry, transarterial therapy and follow-up of liver
cancer patients. I was involved in the radiological evaluation of the
patients with triple phase CT scan using various reconstruction
techniques such as multiplanar image reconstruction (MPR) and maximum
intensity projection (MIP) and DSA guided injection of Re-188-lipiodol
into the tumor after hepatic artery catheterisation. During the course
of this work, I modified and simplified the dosimetric and labeling
techniques, which was discussed and accepted in a IAEA research
co-ordination meeting held in Dec 2003 in New Delhi, published in April
2004 issue of World Journal of Nuclear Medicine and now being followed
by other participating countries. My work was accepted for platform
presentation in the 51st annual meeting of Society of Nuclear Medicine
(SNM), the most prestigious body of Nuclear Medicine, held in June 2004
at Philadelphia, USA and was selected for the highlight session.
Honours/ Distinctions/ Awards/ Medals/ Scholarships
1. Merit Scholarship in School and college
2. Full Scholarship for pursuing “MD” by Medical Council of India, Gvt. of India.
3. MD (General Medicine) with ‘Honours’.
4. Young Scientist/ Travel grant award for year 2000 from Asia-Oceania Federation of nuclear medicine & biology.
5. Travel grant award in 2000 from International Thyroid Congress.
6. Travel Fellow-ship award in 2002 from Indo-American Society of Nuclear Medicine.
7. Young Scientist/ Travel grant award in year 2002 from Asia-Oceania Federation of nuclear medicine & biology.
8. Young Scientist award in year 2003 from Asian Regional Cooperative Council for Nuclear Medicine.
9. Invited to participate and present the work in International
Symposium on Nuclear Oncology, organized by International Atomic Energy
Agency, in Brazil in 2004.
10. Work was selected for presentation in the “highlight
session” by Prof Henry Wagner, in 47th, 49th and 53rd annual
meeting of Society of Nuclear Medicine in years 2000, 2002 and 2004,
respectively.
11. Was made member of National Academy of Medical Sciences, New Delhi, India in 2005.
12. First prize of “young Professional Award” in 2006 from Society of Nuclear Medicine, US.
Experiences:
Working experience: Ten (10) years
-One year in Safdarjung hospital, New Delhi, as resident doctor (1996-97)
-One year in S M Hospital, New Delhi, as resident doctor (1997-98)
-Three years in AIIMS, New Delhi, as resident doctor (1998-2001)
-Two years in AIIMS, New Delhi, as Research Officer (2001-03)
-Two years in AIIMS, New Delhi, as Senior Research Officer (2003-2005)
-One year at CHM, wayne State University, Detroit, US, as Research Associate (2006- )
Teaching experience: Eight (8) years
-Active and compulsory participation in undergraduate and
post-graduate teaching program while pursuing post-graduation and PhD.
-Guidance and help to MSc, MD, DM, MCh students
Reviewer (ad-hoc) for peer-reviewed international journals:
-International Journal of Hepatology
-Brain and Development
-Pediatric Neurology
-Epilepsia
-Developmental Medicine & Child Neurology
Membership of Professional Bodies and Organizations:
-Society of Nuclear Medicine- Northern Chapter (Receipt No. 001/01-22-2000)
-Society of Nuclear Medicine, India (A-39)
-Association of Medical Physicist of Indian (sl. No. 33/08-12-2000)
-Indian Biophysical Society (IBS/L-461)
-Indian College of Nuclear Medicine (No. 102/04-03-2000)
-National Academy of Medical Sciences, India (Ref No: 29-(3)/2004/NAMS/04-18-2005)
Paper Presentation in International and National Conferences:
-2nd Annual Conference of Nuclear Cardiology Society of India, in 1999, in New Delhi, India.
-47th annual meeting of Society of Nuclear Medicine, in 2000 at St Louis, MO, USA.
-12th International Thyroid Congress, in 2000 in Kyoto, Japan.
-33rd Annual Conference of Society of Nuclear Medicine (India), in 2001, in New Delhi, India.
-49th annual meeting of Society of Nuclear Medicine, in 2002 at Los Angeles, CA, USA.
-8th National Conference of Society of Nuclear Medicine, Bangladesh, in 2003, Dhaka, Bangladesh.
-2nd Annual General Meeting of Asia Regional Cooperative Council for
Nuclear Medicine, in 2003,
in Dhaka, Bangladesh.
-6th Asia-Pacific congress of cardiovascular and Interventional Radiology, in 2004, New Delhi, India.
-International Symposium on Nuclear Oncology, in 2004, in Porto Alegre, Brazil.
-53rd annual meeting of Society of Nuclear Medicine, in 2006 at San Diego, CA, USA.
Workshop and CME attended:
-13th International Biophysics Congress, in 1999, in New Delhi, India.
-Regional training workshop on Myocardial Perfusion Scintigraphy using
SPECT for Nuclear Medicine Physicians, organized by International
Atomic Energy agency in 2000, in New Delhi, India.
-Workshop on Alzheimer’s disease, conducted by All India Institute of Medical Science, in 2001, in New Delhi, India.
-National Symposium on “Statistical & Mathematical Techniques
and Radiation Safety in Nuclear Medicine” in 2001, in New Delhi,
India.
-Regional training workshop on Radionuclide Treatment of Liver Cancer,
organized by International Atomic Energy agency (IAEA), in 2002, in Ho
Chi Minh City, Vietnam.
-CME of Society of Nuclear Medicine, in 2002, at Los Angeles, CA, USA.
-CME on Current Perspective in Liver Desease, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.
-Nephrology Update, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.
-CME on “Radiological Protection of Patients in Use of Ionizing
Radiation” and “Management of Radiation Accidents &
Emergencies” in 2002 in Lucknow, India.
-International Symposium on Nuclear Oncology, organized by
International Atomic Energy agency (IAEA), in 2004, in Porto Alegre,
Brazil.
-National Workshop on PET-CT by Indian College of Nuclear Medicine in 2005 in New Delhi, India.
-International Scientific Exchange Program of American Association of Physicists in Medicine in 2006, in New Delhi, India.
-International Symposium on Advances in Diagnostic Medical Physics and
Workshop on “Cyclotron-PET-CT” in 2006 in New Delhi, India.
List of Publications (full papers and abstracts)
1. Bal C S, Kumar A, Dwivedi SN. Radioiodine ablation of contralateral
normal lobe in low-risk carcinoma thyroid patients following
hemithyroidectomy. J Nucl Med 1999; 40: 207
2. Bal C S, Kumar A, Goswami RK. A prospective randomized control trial
to evaluate the adjuvant effect of lithium on radioiodine treatment of
hyperthyrpoidism. J Nucl Med 1999; 40: 209
3. Bal C S, Kumar A, Pant GS. Radioiodine ablation of remaining thyroid
lobe/tissue following hemithyroidectomy or subtotal thyroidectomy in
low-risk patients with differentiated carcinoma thyroid. Ind J Nucl Med
1999; 14: 112.
4. Bal C S, A Kumar, Mukhopadhyaya S. detection of X-Ray negative
pulmonary metastasis by high resolution CT scan in differentiated
thyroid carcinoma and their outcome after radioiodine therapy.
Endocrinol Jap 2000; 47: 135.
5. Gopal V Punjabi, A Kumar, R Goswami, C S Bal. Prevalence of UTI and
detection of renal scars by 99mTc DMSA scanning in diabetes Mellitus- A
case control study. J Nucl Med 2000;
6. Bal C S, Kumar A, S Barai, G V Punjabi, A Naik, G P Bandopadhyaya, S
Aggarwal, A Malhotra, V S Mehta. Role of 99mTc-GHA brain SPECT in
differentiating recurrent glioma from radiation necrosis. EJNM 2000;
27: 997.
7. Ajay kumar, Pandey R M, Bal C S. A prospective randomized control
trial to evaluate the adjuvant effect of Lithium on radioiodine
treatment of hyperthyroidism. Endocrinol Jap 2000; 47: 247.
8. Bal CS, Kumar A, Senthil kumar, G V Punjabi, J B Dasan, Bhatia M,
Padma MV, Gaikwad S, Singh VP, Jain S, Gupta S, Sarkar C. Role of Ictal
and Interictal Tc99m-HMPAO/ECD SPECT in the evaluation of Surgically
remediable epilepsy: Outcome in first 55 operated patients. EJNM 2000;
27: 938.
9. G V Punjabi, M Mighlani, A Kumar, J B Dasan, P K Dave, C S Bal.
Comparison of bone scan and SPECT with structural imaging in diagnosing
cause of low backache. EJNM 2000; 27: 920.
10. Ajay Kumar, Bal C S, Padhy A K. Clinical feature of differentiated
thyroid carcinoma in children and adolescents in endemic iodine
deficient area. Turk J Nucl Med 2000; 9 (3): 67.
11. Bal CS and Ajay Kumar. Radionuclide imaging in Urinary infections. Pediatric Today 2000; 6: 408-410.
12. CS Bal and Ajay kumar. Follicular carcinoma presenting with an isolated scapular metastasis. IJNM 2000; 15(1): 30-32.
13. Bal CS, Padhy AK and Kumar A. Clinical features of differentiated
thyroid carcinoma in children and adolescents from a sub-Himalayan
iodine-deficient endemic zone. Nucl Med Comm, 2001; 22: 881-7.
14. Amite Pankaj, Ajay Kumar, CS Bal et al. Role of three phase bone
scintigraphy in the early diagnosis of reflex sympathetic dystrophy of
the hand. EJNM 2001; 28: 1167.
15. Ajay kumar, CS Bal, Abhijit Ghosh et al. Role of GFR and ERPF in
predicting renal dysfunction in anaemic patients with normal serum
biochemistry. EJNM 2001; 28: 1221-1222.
16. Gopal V Punjabi, Ajay Kumar, CS Bal. Prognostic value of flow
cytometric DNA measurements in Indian Patients with thyroid cancer.
EJNM 2001; 28: 1174.
17. CS Bal, A Kumar and GS Pant. How small should “small
dose” of radioiodine be for remnant ablation in differentiated
thyroid carcinoma: A prospective randomized clinical trial in 372
patients. JNM 2001; 42: 158.
18. Chandrashekar N, Ajay Kumar, M tripathi, Hentok Phom, Thomas EJ and
CS Bal. Evaluation of L,L-Ethyl cysteine in healthy Indian adults. IJNM
2001; 16: 144.
19. N Chandrashekar, S Guleria, M Tripathi, Ajay Kumar and CS Bal. Role
of Tc-99m L, L-ethyl cysteine in evaluation of renal transplant
patients: initial experience. IJNM 2001; 16: 146.
20. CS Bal, K Gupta, A Kumar, Chandrashekar N, V P Choudhury, R
Kashyap, M Mahapatra and A K Padhy. Role of Cr-51-RBC survival studies
in the management of hypersplenism. IJNM 2001; 16: 174.
21. Madhavi T, Chandrashekar N, Thomas EJ, Hentok P, Naveen K, Ajay
Kumar, R Kumar, A Malhotra and CS Bal. Hepatobiliary scintigraphy is
very crucial in the management of bile leak following laparoscopic
cholecystectomy. Nucl Med Comm 2002; 23: 399.
22. Chandrashekar N, Ajay Kumar, Thomas EJ, Madhavi T, Hentok P, Naveen
K, A Malhotra and C S Bal. 99mTc-l,l-ethyl cysteine renal scan as a
single modality investigation for the evaluation of renal morphology
and function: a comparative study with 99mTc-DMSA renal scan. Nucl Med
Comm 2002; 23: 399.
23. A Kumar, N Keshary, H Phom, N Chandrashekar, E J Thomas, M
Tripathi, P S N Menon, K Anand, R M Pandey, C S Bal. A large proportion
of children with Down syndrome suffer from thyroid dysfunction. JNM
2002; 43: 330.
24. A Kumar, H Phom, E J Thomas, N Chandrashekar, M Tripathi, A
Malhotra, R Kashyap, V P Choudhry, C S Bal. Detection of accessory
spleen following splenectomy in cases of chronic Idiopathic
Thrombocytopenic Purpura. JNM 2002; 43: 79-80.
25. E J Thomas, N Chandrashekar, A Kumar, H Phom, M Tripathi, P K
Julka, V P Singh, C S Bal. 99mTc Glucoheptonate Brain SPECT: an
Invaluable Tool in the Management of Post-Operative Patients with
Primary Brain Tumors Receiving Radiotherapy; Correlative Study with CT,
MRI and Clinical Outcome in 140 Patients. JNM 2002; 43: 249.
26. C S Bal, A Kumar. Can Iopanoic Acid (Telepaque) be used for rapid
control of hyperthyroidism prior to 131I therapy: long-term outcome of
a randomized control trial. JNM 2002; 43: 125-126.
27. Tripathi M, Chandrashekar N, Thomas EJ, Naveen K, Ajay Kumar, CS
Bal, A Malhotra. Efficacy of F+0 diuresis renography with 99mTc-EC in
the evaluation of dilated upper tract in infants & children.
EANM-2002; A 2555.
28. A. Kumar, H.Phom, P. Akshay, N. Chandrashekar, M. Tripathi,
E.J.Thomas, M.Srinivas, V. Bhatnagar, C.S. Bal. Evaluation of
cerebral vascular reserve by 99m-Tc-ECD brain Spect: is it a sensitive
prognostic parameter in the management of congenital
hydrocephalus? WFNMB 2002; 2568.
29. A. Kumar, H.Phom, E.J. Thomas, M. Tripathi, N. Chandrashekar, H
Zamir, S. Gulati, V.Kalra, C.S. Bal. Role of 99mTc-ECD brain
SPECT in the detection of cerebral perfusion abnormality in cases of
attention Deficit Hyperactivity Disorder. WFNMB 2002; 2573.
30. A. Kumar, P.Hentok, N. Chandrashekar, E.J. Thomas, M. Tripathi, A.
Ghosh, B.L. Jaikhani, O.P. Malhotra, C.S. Bal. Effect of severe
anaemia on renal function: a case-control study. WFNMB 2002; 2566.
31. Bal CS, Kumar A and Pandey RM. A randomized controlled trial to
evaluate the adjuvant effect of lithium on radioiodine treatment of
hyperthyroidism. Thyroid 2002; 12: 399-406.
32. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Differentiated thyroid
carcinoma in children and adolescents: clinical features and outcome of
radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 4.
33. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Clinical Characteristics
of X-ray negative pulmonary metastasis from differentiated thyroid
carcinoma in children and adolescents and their outcome after
radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 25.
34. Thomas EJ, J. Bharathi Dasan, N. Chandrasekhar, M. Tripathi, R.
Kumar, A. Kumar, D.K. Gupta, D.K. Mitra, A. Malhotra. Detection of
gastroesophageal reflux in survivors of congenital diaphragmatic
hernia: A radionuclide scintigraphic study in 26 children. WFNMB 2002:
1; A 320.
35. Thomas EJ, J. Bharathi Dasan, R. Kumar, N. Chandershekher, M.
Tripathi, A. Kumar, S. Menon, S.K. Kabra, A. Malhotra. Silent
gastro-esphageal reflux in children presenting with recurrent lower
respiratory tract infections. WFNMB 2002: 1; A 321.
36. Thomas EJ, M. Hadi, M. Tripathi, A. Kumar, J. Bharathi Dasan, N.
Chandershekhar, S. Agarwala, C.S. Bal, R. Kumar. Direct radionuclide
cystography by suprapublic puncture method – a comparison with
micturating cystouretherography in 45 children on follow up for vesico
ureteric reflux. WFNMB 2002: 1; A 322.
37. Bal CS, Kumar A, Padhy AK, Bahadur S. Role of bone scan in the
management of squamous cell carcinoma of oral cavity. World J Nucl Med
2002; 1:29-34.
38. Y G Rao, Ajay Kumar, G K Pande, P Sahni, T K Chattopadhyay, K
Gupta, S Aggarwal, G P Bandopadhyay and C S Bal. Role of 99mTc-DTPA GFR
estimation in the evaluation of the effect of preoperative hydration
and low dose dopamine infusion on renal function in patients undergoing
surgery for obstructive jaundice. BJNM 2003. 6; 62-63.
39. Ajay Kumar, Srinivasan J V, Phom H, Chandrashekhar N, Tripathi M, C
S Bal. Role of bone scan in assessing the fracture healing and
predicting the outcome of fracture shaft femur, managed by rimmed
intramedullary interlocking. JNM 2003; 44: A 652687.
40. Ajay Kumar, G S Pant, C S Bal. Clinical characteristics of
pulmonary metastasis from differentiated thyroid carcinoma in children
and adolescents and their outcome after radioiodine therapy. JNM 2003;
44: A 652678.
41. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K
Acharya, K R sundaram and G S Pant. Role of dosimetry in transarterial
Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular
carcinoma. World congress on Medical Physics and Biomedical Engineering
2003: A 2065.
42. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K
Acharya, K R sundaram and G S Pant. Is scatter correction necessary for
the dosimetry in transarterial Re-188 labeled lipiodol therapy in cases
of inoperable hepatocellular carcinoma? World congress on Medical
Physics and Biomedical Engineering 2003: A 2069.
43. A Kumar, P Chandra, N K Gowda, N Murali, S Choudhury, N
Chandrasheker, S Sen, J Bharathidasan, S Aggarwal, G P Bandopadhyaya
and C S Bal. Critical evaluation of the role of 99mTc-sestamibi (MIBI)
and 99mTc-tetrofosmin (TF) in post-surgical follow-up of the patients
with differentiated thyroid cancer: a clinical trial. JSNM 2003.
44. Kumar A, Bal CS. Differentiated Thyroid Cancer. Ind J Pediatr 2003; 70:707-713.
45. C S Bal, Ajay Kumar, M Tripathi, and G S Pant. High dose
radioiodine treatment is not associated with change in fertility or any
genetic risk to the offspring. Ind J Nucl Med 2003; 18 (4): 22-23.
46. M Tripathi, N Chandrasekhar, N K Gowda, A Kumar, C S Bal.
Effectiveness of Sm-153 therapy in pain palliation from skeletal
metastases of carcinoma breast and carcinoma prostate. Ind J Nucl
Med 2003; 18 (4): 22.
47. Bal CS, Kumar A, Pant GS. Radioiodine lobar ablation as an
alternative to completion thyroidectomy in patients with differentiated
thyroid cancer. Nucl Med Comm 2003; 24: 120-6.
48. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P
Bandopadhyaya, G K Pandey, S DattaGupta, K R sundaram, Pat Zanzonico,
Felix X Sundaram, A K Padhy and C S Bal. Transarterial Re-188 labeled
lipiodol therapy in cases of inoperable hepatocellular carcinoma. WJNM
2004; 3: S130-131.
49. Bal CS, Kumar A, Chandra P, Dwivedi SN, Mukhopadhyaya S. Is Chest
X-ray or High-Resolution Computed Tomography Scan of the Chest
Sufficient Investigation to Detect Pulmonary Metastasis in Pediatric
Differentiated Thyroid Cancer? Thyroid 2004; 14: 221-229.
50. Narayana C, Tripathi M, Kumar A, Gowda NK, Phom H, Chandra P,
Bandopadhyaya G, Bal C. Technetium-99m-L,L-ethylenedicysteine renal
scan as a single-modality investigation for the evaluation of renal
morphology and function: a comparative study with
technetium-99m-dimercaptosuccinic acid. Nucl Med Commun. 2004 Jul;
25(7):743-747.
51. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P
Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C
S Bal. Trans-hepatic-arterial Re-188 labeled lipiodol therapy (TART) in
cases of inoperable hepatocellular carcinoma (IHCC)- a prospective
clinical trial. JNM 2004; 45 (5):147P-148P.
52. A Kumar, M R Nadig, P Chandra, M Sahoo, G S Pant and C S Bal. Can
radioiodine ablation be an effective alternative to completion
thyroidectomy in patients undergoing subtotal thyroidectomy (STT) and
if yes, what is the optimum 131I administered activity required: a
prospective clinical trial. JNM 2004; 45 (5):19P.
53. N Chandrashekar, M Tripathi, A Kumar, N K Gowda, M R Nadig, C
Patel, A Malhotra, S Guleria and C S Bal. Evaluation of 99mTc-L,L-Ethyl
Cysteine in renal transplant patients: A comparative study with
99mTc-MAG3 and 131I-OIH. JNM 2004; 45 (5):314P.
54. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P
Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C
S Bal. Dosimetric and therapeutic evaluation of trans-arterial
Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC)-a
prospective multicentric clinical trial. 8th AOFNMB 2004; A213.
55. Bal CS, Kumar A, Pant GS. Radioiodine dose for remnant ablation in
differentiated thyroid carcinoma: a randomized clinical trial in 509
patients. J Clin Endocrinol Metab. 2004 Apr; 89(4):1666-73.
56. Phom H, Kumar A, Tripathi M, Chandrashekar N, Choudhry VP, Malhotra
A, Bal CS. Comparative evaluation of Tc-99m-heat-denatured RBC and
Tc-99m-anti-D IgG opsonized RBC spleen planar and SPECT scintigraphy in
the detection of accessory spleen in postsplenectomy patients with
chronic idiopathic thrombocytopenic purpura. Clin Nucl Med. 2004 Jul;
29(7): 403-9.
57. D N Srivastava, Ajay Kumar, S K Acharya, Sanjay Thulkar, Sanjay
Sharma, G K Pandey, S Duttagupta, K R Sundaram, G P Bandopadhyaya, G S
Pant, A Malhotra and C S Bal. Trans-arterial radionuclide therapy
(TART) in cases of inoperable hepatocellular carcinoma (HCC)- a
prospective clinical trial. 6th APCCIR 2004: 324-325.
58. G Bhaskar, A Kumar, P Chandra, S Gulati, A K Gupta, V Kalra, C S
Bal. Prevalence of gastroesophageal reflux in children with
developmental delay: A prospective clinical trial. J. Nucl Med
2005; 46: 224P.
59. S Kattimani, A Kumar, R Sagar, C S Bal. Role of 99mTc-ECD
Brain SPECT in the evaluation of patients with catatonia: A prospective
clinical Trial. J Nucl Med 2005; 46: 215P.
60. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, and Bal CS.
Adrenal and Renal Metastases from Follicular Thyroid Cancer. BJR 2005;
78: 1038-1041.
61. Bal C, Kumar A, Tripathi M, Chandrashekar N, Phom H, Murali NR,
Chandra P, Pant GS. High-dose radioiodine treatment for
differentiated thyroid carcinoma is not associated with change in
female fertility or any genetic risk to the offspring. Int J Radiat
Oncol Biol Phys 2005; 63: 449-455.
62. CS Bal, T Singhal, K Naveen, M Tripathi, GS Pant, CD Patel, R
Kumar, A Kumar, SK Saw, A Malhotra. 18F-FDG PET-CT in 131I WBS negative
thyroid cancer: an initial experience. IJNM 2005; 20 (4): 119.
63. Kumar A, Bal CS, Srivastava DN, Acharya SK, Thulkar S, Sharma S,
Duttagupta S. Transarterial Radionuclide Therapy with
Re-188-HDD-lipiodol in Case of Unresectable Hepatocellular Carcinoma
with Extensive Portal Vein Thrombosis. EJR (extra) 2005; 2005; 56 (2):
55-59.
64. Bal CS and Kumar A. Alternative Strategies in the Management of
De-Differentiated Thyroid Cancer. Ind J Oncol 2005; 26: 28-41.
65. Bal CS, Kumar A, Chandra P. Effect of Iopanoic Acid (Telepaque) on
Radioiodine Therapy of Hyperthyroidism: Long-Term Outcome of a
Randomized Controlled Trial. JCEM 2005; 90: 6536-6540.
66. CS Bal, T Singhal, R Kumar, R Verma, P Chandra, A Kumar, GS Pant.
Long term outcome of radioiodine lobar ablation in patients with
differentiated thyroid cancer. JNM 2006; 47 (Suppl 1): 324.
67. A Kumar, C Bal, DN Srivastava, P Chandra, SK Acharya, GS Pant, GP
Bandopadhyaya. Dosimetric and therapeutic evaluation of trans-arterial
Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC). JNM
2006; 47 (Suppl 1): 105.
68. A Kumar, C Bal and DN Srivastava. Modified labeling technique of
Rhenium (Re)-188-HDD lipiodol for transarterial radionuclide therapy in
liver cancer. JNM 2006; 47 (Suppl 1): 528.
69. Prem Chandra, CS Bal, SN Dwivedi, Ajay Kumar, Arvind Pandey. An
applicability of imputation analysis in clinical trial on remnant
ablation in differentiated thyroid cancer. Clinical Trials 2006; 3(1):
208
70. Kumar A, Bal C, Srivastava DN, Thulkar SP, Sharma S, Acharya SK,
Duttagupta S. Management of multiple intrahepatic recurrences
after radiofrequency ablation of hepatocellular carcinoma with
rhenium-188-HDD-lipiodol. Eur J Gastroenterol Hepatol 2006;18(2):
219-23.
71. Kumar A, Srivastava DN, Bal CS. Management of Post-Surgical
Recurrence of Hepatocellular Carcinoma with Transarterial Radionuclide
Therapy. J Vasc Interv Radiol 2006; 17(1): 157-61.
72. CS Bal, Ajay Kumar, Prem Chandra, S N Dwivedi, G S Pant. A
prospective clinical trial to assess the efficacy of radioiodine
ablation as an alternative to completion thyroidectomy in patients with
differentiated thyroid cancer undergoing sub-total thyroidectomy. Acta
Oncol. 2006;45(8):1067-72.
73. Ajay Kumar, DN Srivastava, Trinh Thi Minh Chau, Huynh Duc Long, CS
Bal, Prem Chandra, Le Truong Chien, Nguyen Van Hoa, S Thulkar, S
Sharma, Le Huu Tam, Truong Quang Xuan, Nguyen Xuan Canh, GS Pant, GP
Bandopadhyaya. Transarterial Re-188-HDD-Lipiodol in the treatment of
Inoperable Hepatocellular Carcinoma: a Prospective Multicenter Clinical
Trial. Radiology 2007; 243:509-519.
74. Prem Chandra S.N. Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey.
Utility of imputation analysis in clinical trial on remnant ablation of
differentiated thyroid cancer patients. Accepted for publication in
“Statistics in Transition”.
75. Bernal Patricia, Raoul Jean-Luc, Vidmar Gay, Sereegotov C, Sundram
Felix X, Kumar A, J-M Jeong, Pusuwan P, Divgi Chaitanya, Zanzonico Pat,
Stare Janez, Chau T, Saw M, Chen SL, Ogbac R, Buscombe JR, Padhy Ajit
K. Intra-arterial Rhenium-188 Lipiodol in the treatment of inoperable
hepatocellular carcinoma: results of an IAEA-sponsored multi-nation
study. Accepted for publication in “International Journal of
Radiation Oncology, Biology, Physics”.
List of Publications (Book chapters)
1. CS Bal and Ajay Kumar. “Radionuclide imaging” In
“Pediatric Nephrology” RN Srivastav and A Bagga (eds), 3rd
Edition, Jaypee Brothers , New Delhi, 2001, pp39-49.
2. CS Bal & A Kumar. “Radioisotopes and their applications in
Medicine”. In “Text Book of Biochemistry and Human
Biology”. GP Talwar and LM Srivastav (eds), Pritice Hall India,
New Delhi,2002,pp1189-1214.
3. CS Bal and Ajay Kumar. Radionuclide imaging. In R N Srivastava and A
Bagga eds. Pediatric Nephrology. New Delhi: Jaypee Brothers, 2004:
45-57.
4. CS Bal and Ajay Kumar. Nuclear Imaging in vesico-ureteric reflux. In
M Bajpai, J P Gearhart, K Hjalmas eds. Progress in pediatric Urology.
New Delhi: Penwel publishers plc, 2005: 50-59.
5. CS Bal and Ajay Kumar. “Role of Radionuclide Investigations in
Surgical Practices”. In “Essentials of Surgery”.
Sunil Chumbar(ed), Jaypee Brothers, New Delhi, 2005; 336-344.
6. Prem Chandra, SN Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey, KR
Sundaram, Padam Singh. On the use of consort statement in clinical
trial on remnant ablation of differentiated thyroid cancer. In Arvind
Pandey ed. Biostatistical aspects of health and population. New Delhi:
Hindustan publishing corporation (India), 2006: 41-45.
7. Bal CS and Ajay Kumar. Nuclear Imaging in Paediatric Surgery. In D K Gupta ed. Pediatric Surgery. (in press)
8. CS Bal and Ajay Kumar. Differentiated Thyroid Cancer in Childhood
and Adolescence. In “An International Perspective of Thyroid
Cancer: a practical approach to management and related issues”,
IAEA, Vienna, (in press).
9. CS Bal and Ajay Kumar. Prognostic factors and risk group analyses in
patients with differentiated thyroid carcinoma. In “An
International Perspective of Thyroid Cancer: a practical approach to
management and related issues”, IAEA, Vienna, (in press).
10. CS Bal and Ajay Kumar. Role of Chemotherapy in the management of
Thyroid Carcinoma. In “An International Perspective of Thyroid
Cancer: a practical approach to management and related issues”,
IAEA, Vienna, (in press).
11. CS Bal and Ajay Kumar. Thyroglobulin. In “An International
Perspective of Thyroid Cancer: a practical approach to management and
related issues”, IAEA, Vienna, (in press).
12. Sundaram SK, Ajay Kumar and GP Bandopadhyaya. Radiopharmaceuticals in clinical nuclear medicine. In GS Pant ed. (in press)
13. Sundaram SK and Ajay Kumar. PET Quantification. In GS Pant ed. (in press)
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